Advanced search
User account
Login
Register
Find models by
Model name
First author
Each author
Find models for
Brain region
Concept
Find models of
Realistic Microcircuits
Connectionist Networks
Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
Download zip file
Auto-launch
Help downloading and running models
Model Information
Model File
Versions
Accession:
155601
Among the rhythmic firing patterns observed in brain, gamma oscillations, which are involved in memory formation and retrieval, are generated by networks of fast-spiking basket cells (FS-BCs) with robust interconnectivity through fast GABA synapses. Recently, we identified presence of extrasynaptic tonic GABA currents in FS-BCs and showed that experimentally-induced seizures enhance extrasynaptic tonic GABA currents and render GABA reversal potential (EGABA) depolarizing (Yu et al., 2013). Extrasynaptic GABA currents are mediated by extra- and peri-synaptically located GABAARs and can contribute to synaptic decay kinetics. Additionally, shunting rather than hyperpolarizing EGABA has been shown to increase the frequency and reduce coherence of network oscillations. Using homogeneous networks of biophysically-based, multi-compartmental model FS-BCs, we examined how the presence of extrasynaptic GABA currents and the experimentally identified seizure-induced alterations in GABA currents and EGABA modify the frequency and coherence of network firing.
Reference:
1 .
Proddutur A, Yu J, Elgammal FS, Santhakumar V (2013) Seizure-induced alterations in fast-spiking basket cell GABA currents modulate frequency and coherence of gamma oscillation in network simulations.
Chaos
23
:046109
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Dentate gyrus basket cell;
Channel(s):
Gap Junctions:
Gap junctions;
Receptor(s):
GabaA;
Gene(s):
Transmitter(s):
Gaba;
Simulation Environment:
NEURON;
Model Concept(s):
Oscillations;
Implementer(s):
Search NeuronDB
for information about:
GabaA
;
Gaba
;
/
ProdduturEtAl2013
readme.html
bgka.mod
*
Other models using bgka.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
CaBK.mod
*
Other models using CaBK.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
ccanl.mod
*
Other models using ccanl.mod:
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
gap.mod
Gfluct2.mod
*
Other models using Gfluct2.mod:
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
gskch.mod
*
Other models using gskch.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
hyperde3.mod
*
Other models using hyperde3.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
ichan2.mod
*
Other models using ichan2.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate Gyrus Feed-forward inhibition (Ferrante et al. 2009)
Dentate Gyrus Feed-forward inhibition (Ferrante et al. 2009)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Parallel network simulations with NEURON (Migliore et al 2006)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
izap.mod
LcaMig.mod
*
Other models using LcaMig.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
markov.mod
*
Other models using markov.mod:
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
nca.mod
*
Other models using nca.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
tca.mod
*
Other models using tca.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
tonic.mod
*
Other models using tonic.mod:
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
IClamp 50% gaps 30 SYNAPSES tonicspill -74mV_0.6nA.hoc
PPSTIM 50% gaps 30 SYNAPSES tonicspill -74mV.hoc
screenshot1.png
File not selected
<- Select file from this column.
