CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)

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Accession:157157
This NEURON code implements a microcircuit of CA1 pyramidal neuron and consists of a detailed model of CA1 pyramidal cell and four types of inhibitory interneurons (basket, bistratified, axoaxonic and oriens lacunosum-moleculare cells). Synaptic plasticity during theta cycles at a synapse in a single spine on the stratum radiatum dendrite of the CA1 pyramidal cell is modeled using a phenomenological model of synaptic plasticity (Graupner and Brunel, PNAS 109(20):3991-3996, 2012). The code is adapted from the Poirazi CA1 pyramidal cell (ModelDB accession number 20212) and the Cutsuridis microcircuit model (ModelDB accession number 123815)
Reference:
1 . Saudargiene A, Cobb S, Graham BP (2015) A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus 25:208-18 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Long-term Synaptic Plasticity; STDP;
Implementer(s): Saudargiene, Ausra [ausra.saudargiene at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell;
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SaudargieneEtAl2015
readme.html
ANsyn.mod *
bgka.mod *
bistableGB_DOWNUP.mod
burststim2.mod *
cad.mod
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kadbru.mod
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kca.mod *
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my_exp2syn.mod *
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nap.mod
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STDPE2Syn.mod *
apical-non-trunk-list.hoc
apical-tip-list.hoc
apical-tip-list-addendum.hoc
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axoaxonic_cell17S.hoc
axon-sec-list.hoc
BasalPath.hoc
basal-paths.hoc
basal-tree-list.hoc
basket_cell17S.hoc
bistratified_cell13S.hoc
burst_cell.hoc
current-balance.hoc *
main.hoc
map-segments-to-3d.hoc *
mod_func.c
mosinit.hoc
ObliquePath.hoc *
oblique-paths.hoc
olm_cell2.hoc
pattsN100S20P5_single.dat
PC.ses
peri-trunk-list.hoc
pyramidalNeuron.hoc
randomLocation.hoc
ranstream.hoc
screenshot.png
soma-list.hoc
stim_cell.hoc *
vector-distance.hoc
                            
// This function is used to balance the membrane potential to v_init (= -70 mV)
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

proc current_balance() {

 // print "Note: This does not account for non-specific ion currents.\n"

  finitialize($1)
  fcurrent()

  printf("Balancing each compartment to %d mV\n", $1)

  forall {
      for (x) {
        if (ismembrane("na_ion") && ismembrane("ca_ion") && ismembrane("Ca_ion") && (ismembrane("k_ion"))) {
            e_pas(x)=(ina(x)+ik(x)+ica(x)+iCa(x)+g_pas(x)*v(x))/g_pas(x) 
        } else if (ismembrane("na_ion") && ismembrane("ca_ion") && (ismembrane("k_ion"))){
            e_pas(x)=(ina(x)+ik(x)+ica(x)+g_pas(x)*v(x))/g_pas(x) 
        } else if (ismembrane("na_ion") && (ismembrane("k_ion"))) {
            e_pas(x)=(ina(x)+ik(x)+g_pas(x)*v(x))/g_pas(x)
          //printf("Section %s ina: %g ik: %g\n", secname(), ina(x), ik(x))
          //psection()
        } else {
          print "simply assigning v(x)"
          e_pas(x)=v(x)
        }
      fcurrent()
    }
  }
}