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Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
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Model Information
Model File
Accession:
157339
NEURON mod files from the paper: M. Migliore, et al. (2015). In this paper, we investigate the possibility that the experimental protocols on synaptic plasticity may result in different consequences (e.g., LTD instead of LTP), according to the initial conditions of the stimulated synapses, and can generate confusing results. Using biophysical models of synaptic plasticity and hippocampal CA1 pyramidal neurons, we study how, why, and to what extent EPSPs observed at the soma after induction of LTP/LTD reflects the actual (local) synaptic state. The model and the results suggest a physiologically plausible explanation of why LTD induction is experimentally difficult, and they offer experimentally testable predictions on the stimulation protocols that may be more effective.
Reference:
1 .
Migliore M, De Simone G, Migliore R (2015) Effect of the initial synaptic state on the probability to induce long-term potentiation and depression.
Biophys J
108
:1038-46
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Synapse;
Dendrite;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Na,t;
I A;
I K;
I h;
Gap Junctions:
Receptor(s):
AMPA;
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Long-term Synaptic Plasticity;
Implementer(s):
Migliore, Michele [Michele.Migliore at Yale.edu];
Migliore, Rosanna [rosanna.migliore at cnr.it];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
AMPA
;
I Na,t
;
I A
;
I K
;
I h
;
Glutamate
;
Download the displayed file
/
MiglioreEtAl2015
readme.html
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Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
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Effects of electric fields on cognitive functions (Migliore et al 2016)
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CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
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Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Channel density variability among CA1 neurons (Migliore et al. 2018)
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Effects of electric fields on cognitive functions (Migliore et al 2016)
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Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
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Model of CA1 activity during working memory task (Spera et al. 2016)
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Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
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CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
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CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
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CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
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Effects of electric fields on cognitive functions (Migliore et al 2016)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
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Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
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Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
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mosinit.hoc
screenshot.png
load_file("nrngui.hoc") xopen("fig1C.hoc")
