// Network cell template
// CA1PyramidalCell
// Geometry: 14 sections + axon
// Active properties: from Poirazi et al, Neuron 2003
// Adjusted to get more decrementing BPAP
// BPG & VCU, 2-1-09
begintemplate CA1PyramidalCell
public is_art
public init, topol, basic_shape, subsets, geom, biophys
public pre_list, connect2target
public soma, radTprox, radTmed, radTdist, lm_thick2, lm_medium2, lm_thin2
public lm_thick1, lm_medium1, lm_thin1, oriprox1, oridist1, oriprox2, oridist2
public axon
public all
objref pre_list
proc init() {
topol()
subsets()
geom()
biophys()
geom_nseg()
pre_list = new List()
synapses()
}
create soma, oriprox1, oridist1, oriprox2, oridist2, axon, radTprox
create radTmed, radTdist, lm_thick2, lm_medium2, lm_thin2, lm_thick1, lm_medium1
create lm_thin1, radTprox_obl2, radTprox_obl1, radTdist_obl2, radTdist_obl1
proc topol() { local i
connect oriprox1(0), soma(0)
connect oridist1(0), oriprox1(1)
connect oriprox2(0), soma(1)
connect oridist2(0), oriprox2(1)
connect axon(0), soma(0)
connect radTprox(0), soma(1)
connect radTmed(0), radTprox(1)
connect radTdist(0), radTmed(1)
connect lm_thick2(0), radTdist(1)
connect lm_medium2(0), lm_thick2(1)
connect lm_thin2(0), lm_medium2(1)
connect lm_thick1(0), radTdist(1)
connect lm_medium1(0), lm_thick1(1)
connect lm_thin1(0), lm_medium1(1)
connect radTprox_obl2(0), radTprox(1)
connect radTprox_obl1(0), radTprox(1)
connect radTdist_obl2(0), radTmed(1)
connect radTdist_obl1(0), radTmed(1)
basic_shape()
}
proc basic_shape() {
soma {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(15, 0, 0, 1)}
oriprox1 {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(-14, -14, 0, 1)}
oridist1 {pt3dclear() pt3dadd(-14, -14, 0, 1) pt3dadd(-44, -29, 0, 1)}
oriprox2 {pt3dclear() pt3dadd(15, 0, 0, 1) pt3dadd(30, -14, 0, 1)}
oridist2 {pt3dclear() pt3dadd(30, -14, 0, 1) pt3dadd(60, -29, 0, 1)}
axon {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(0, -89, 0, 1)}
radTprox {pt3dclear() pt3dadd(15, 0, 0, 1) pt3dadd(15, 30, 0, 1)}
radTmed {pt3dclear() pt3dadd(15, 30, 0, 1) pt3dadd(15, 60, 0, 1)}
radTdist {pt3dclear() pt3dadd(15, 60, 0, 1) pt3dadd(15, 90, 0, 1)}
lm_thick2 {pt3dclear() pt3dadd(15, 90, 0, 1) pt3dadd(30, 105, 0, 1)}
lm_medium2 {pt3dclear() pt3dadd(30, 105, 0, 1) pt3dadd(45, 120, 0, 1)}
lm_thin2 {pt3dclear() pt3dadd(45, 120, 0, 1) pt3dadd(60, 135, 0, 1)}
lm_thick1 {pt3dclear() pt3dadd(15, 90, 0, 1) pt3dadd(0, 105, 0, 1)}
lm_medium1 {pt3dclear() pt3dadd(0, 105, 0, 1) pt3dadd(-14, 120, 0, 1)}
lm_thin1 {pt3dclear() pt3dadd(-14, 120, 0, 1) pt3dadd(-29, 135, 0, 1)}
radTprox_obl2 {pt3dclear() pt3dadd(15, 30, 0, 1) pt3dadd(45, 45, 0, 1)}
radTprox_obl1 {pt3dclear() pt3dadd(15, 30, 0, 1) pt3dadd(-14, 45, 0, 1)}
radTdist_obl2 {pt3dclear() pt3dadd(15, 60, 0, 1) pt3dadd(30, 75, 0, 1)}
radTdist_obl1 {pt3dclear() pt3dadd(15, 60, 0, 1) pt3dadd(-14, 90, 0, 1)}
}
objref all
proc subsets() { local i
objref all
all = new SectionList()
soma all.append()
oriprox1 all.append()
oridist1 all.append()
oriprox2 all.append()
oridist2 all.append()
axon all.append()
radTprox all.append()
radTmed all.append()
radTdist all.append()
lm_thick2 all.append()
lm_medium2 all.append()
lm_thin2 all.append()
lm_thick1 all.append()
lm_medium1 all.append()
lm_thin1 all.append()
radTprox_obl2 all.append()
radTprox_obl1 all.append()
radTdist_obl2 all.append()
radTdist_obl1 all.append()
}
proc geom() {
soma { L = 10 diam = 10 }
// SR is first 500um of apical dendrite
radTprox { L = 100 diam = 4 } // L = 100 diam = 4
radTmed { L = 100 diam = 3 } // L = 100 diam = 3
radTdist { L = 200 diam = 2 } // L = 200 diam = 2
radTprox_obl1 { L = 100 diam = 4 }
radTprox_obl2 { L = 100 diam = 4 }
radTdist_obl1 { L = 100 diam = 2 }
radTdist_obl2 { L = 100 diam = 2 }
// LM is final 300um of apical dendrite
lm_thick2 { L = 100 diam = 2 } // L = 100 diam = 2
lm_medium2 { L = 100 diam = 1.5 }
lm_thin2 { L = 50 diam = 1 }
lm_thick1 { L = 100 diam = 2 } // L = 100 diam = 2
lm_medium1 { L = 100 diam = 1.5 }
lm_thin1 { L = 50 diam = 1 }
// Basal dendrites extend 300 um
oriprox1 { L = 100 diam = 2 }
oridist1 { L = 200 diam = 1.5 }
oriprox2 { L = 100 diam = 2 }
oridist2 { L = 200 diam = 1.5 }
// Short section of axon
axon { L = 150 diam = 1 }
}
external lambda_f
proc geom_nseg() {
forsec all { nseg = int((L/(0.1*lambda_f(100))+.9)/2)*2 + 1 }
}
proc biophys() {
forsec all {
// Rm = 28000 // Ohm.cm^2 (Migliore value)
Rm = 20000 // Ohm.cm^2 (Migliore value)
// gka_soma = 0.0075
// gka_soma = 0.005
gka_soma = 0.0025
gh_soma = 0.00005
}
soma {
insert hha2 // HH mechanism with low threshold for Na spikes (-57 mV)
gnabar_hha2 = 0.007
gkbar_hha2 = 0.007/5
gl_hha2 = 0
el_hha2 = -70
insert pas // leak conductance
g_pas = 1/Rm
insert hd2 // h current according to Migliore et al. 2004
// ghdbar_hd = 0
ghdbar_hd = gh_soma
vhalfl_hd = -73
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043 // anything above 0.000043 gives hyperpolarizing oscillations
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert kap // proximal A current
// gkabar_kap = 0.00075
gkabar_kap = gka_soma //0.0075
insert km // m-type potassium current
gbar_km = 0.06
insert cal // HVA Ca++-L type current
//gcalbar_cal = 0.014/2
gcalbar_cal = 0.0014/2
insert cat // LVA Ca++-T type current
gcatbar_cat = 0.0001/2
insert somacar // HVAm Ca++-R type current
// gcabar_somacar = 0.003
gcabar_somacar = 0.0003
insert kca // K(Ca) sAHP potassium type current
gbar_kca = 5*0.0001
// gbar_kca = 0
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 0.09075
// gkbar_cagk2 = 0
insert cad // calcium pump/buffering mechanism
}
radTprox {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = 2*gh_soma //0.000005
// ghdbar_hd = 7*gh_soma //0.000005
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043 // anything above 0.000043 gives hyperpolarizing oscillations
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
gcalbar_calH = 0.1*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
// gcalbar_calH = 4.6*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
// gbar_kca = 0 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 2*0.0165
// gkbar_cagk2 = 0
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
gkabar_kap = 2*gka_soma //0.0075
// gkabar_kap = 0.00075 //0.0075
insert kad
// gkabar_kad = 0.00075
gkabar_kad = 6*gka_soma
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
radTprox_obl1 {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = 2*gh_soma //0.000005
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043 // anything above 0.000043 gives hyperpolarizing oscillations
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
gcalbar_calH = 0.1*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
// gbar_kca = 0 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 2*0.0165
// gkbar_cagk2 = 0
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
gkabar_kap = 2*gka_soma //0.0075
// gkabar_kap = 0.00075
insert kad
// gkabar_kad = 0.00075
gkabar_kad = 2*gka_soma
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
radTprox_obl2 {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = 2*gh_soma //0.000005
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043 // anything above 0.000043 gives hyperpolarizing oscillations
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
// gcalbar_calH = 0.1*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
gcalbar_calH = 10*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
// gbar_kca = 0 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 2*0.0165
// gkbar_cagk2 = 0
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
gkabar_kap = 2*gka_soma //0.0075
// gkabar_kap = 0.00075
insert kad
// gkabar_kad = 0.00075
gkabar_kad = 2*gka_soma
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
radTmed {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = 4*gh_soma // 0.000005
// ghdbar_hd = 7*gh_soma // 0.000005
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car // HVAm Ca++-R type current
gcabar_car = 0.1*0.0003
insert calH // HVA L-type Ca2+ channel used in distal dendrites to account for
// distally restricted initiation of Ca2+ spikes
// gcalbar_calH = 4.6*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
gcalbar_calH = 10*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
insert cat // HVA T-type Ca2+ channel
gcatbar_cat = 0.0001 // 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
// gbar_kca = 0 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 2*0.0165
// gkbar_cagk2 = 0
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
gkabar_kap = 0
insert kad
gkabar_kad = 4*gka_soma
// gkabar_kad = 0.00075
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
radTdist {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = 7*gh_soma // 0.000005
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
// gcalbar_calH = 4.6*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
gcalbar_calH = 10*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 0.5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
// gbar_kca = 0 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 0
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
gkabar_kap = 0
insert kad
gkabar_kad = 6*gka_soma
// gkabar_kad = 0.00075
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
radTdist_obl1 {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = 7*gh_soma // 0.000005
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
// gcalbar_calH = 4.6*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
gcalbar_calH = 10*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 0.5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
// gbar_kca = 0 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 0.25*0.0165
// gkbar_cagk2 = 0
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
gkabar_kap = 0
insert kad
gkabar_kad = 6*gka_soma
// gkabar_kad = 0.00075
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
radTdist_obl2 {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = 7*gh_soma // 0.000005
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
// gcalbar_calH = 4.6*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
gcalbar_calH = 10*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 0.5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
// gbar_kca = 0 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 0.25*0.0165
// gkbar_cagk2 = 0
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
gkabar_kap = 0
insert kad
gkabar_kad = 6*gka_soma
// gkabar_kad = 0.00075
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
lm_thick2 {
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
gl_hha_old = 0
insert pas // passive properties
g_pas = 1/200000
insert kad // Insert basal A current
gkabar_kad = 6.5*gka_soma
// gkabar_kad = 0.00075
}
lm_medium2 {
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
gl_hha_old = 0
insert pas // passive properties
g_pas = 1/200000
insert kad // Insert basal A current
gkabar_kad = 6.5*gka_soma
// gkabar_kad = 0.00075
}
lm_thin2 {
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
gl_hha_old = 0
insert pas // passive properties
g_pas = 1/200000
insert kad // Insert basal A current
gkabar_kad = 6.5*gka_soma
// gkabar_kad = 0.00075
}
lm_thick1 {
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
gl_hha_old = 0
insert pas // passive properties
g_pas = 1/200000
insert kad // Insert basal A current
gkabar_kad = 6.5*gka_soma
// gkabar_kad = 0.00075
}
lm_medium1 {
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
gl_hha_old = 0
insert pas // passive properties
g_pas = 1/200000
insert kad // Insert basal A current
gkabar_kad = 6.5*gka_soma
// gkabar_kad = 0.00075
}
lm_thin1 {
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
gl_hha_old = 0
insert pas // passive properties
g_pas = 1/200000
insert kad // Insert basal A current
gkabar_kad = 6.5*gka_soma
// gkabar_kad = 0.00075
}
oriprox1 {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = gh_soma
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043 // anything above 0.000043 gives hyperpolarizing oscillations
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
gcalbar_calH = 0.1*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 2*0.0165
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
gkabar_kap = gka_soma //0.0075
// gkabar_kap = 0.00075
insert kad
gkabar_kad = 0
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
oridist1 {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = 2*gh_soma
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043 // anything above 0.000043 gives hyperpolarizing oscillations
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
gcalbar_calH = 0.1*0.00031635 // varies from 4.6*0.00031635 to 0.1*0.00031635
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 2*0.0165
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
gkabar_kap = gka_soma //0.0075
// gkabar_kap = 0.00075
insert kad
gkabar_kad = 0
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
oriprox2 {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = gh_soma
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043 // anything above 0.000043 gives hyperpolarizing oscillations
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
gcalbar_calH = 0.1*0.00031635 // varies from .1*0.00031635 to 4.6*0.00031635 as distance increases
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 2*0.0165
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
// gkabar_kap = 0.0075 //0.0075
gkabar_kap = 0.00075
insert kad
gkabar_kad = 0
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
oridist2 {
insert hd2 // h current according to Migliore et al. 2004
ghdbar_hd = 2*gh_soma
vhalfl_hd = -81
// insert hNa // h current according to Poirazi 2003
// gbar_h = 0.000043 // anything above 0.000043 gives hyperpolarizing oscillations
// gbar_h = 1.872e-5
// K_h = 8.8
// vhalf_h = -82
insert car
gcabar_car = 0.1*0.0003
insert calH
gcalbar_calH = 0.1*0.00031635 // varies from 4.6*0.00031635 to 0.1*0.00031635
insert cat
gcatbar_cat = 0.0001
insert cad // calcium pump/buffering mechanism
insert kca // slow AHP K+ current
gbar_kca = 5*0.0001 // varies depending on distance from 0.5*0.0001 to 5*0.0001
insert cagk2 // medium AHP K++ current
gkbar_cagk2 = 2*0.0165
insert km // m-type K current
gbar_km = 0.06 // varies with distance (see Poirazzi et al. 2003 cell-setup.hoc file)
insert kap // Inserting A-current
// gkabar_kap = 0.0075 //0.0075
gkabar_kap = 0.00075
insert kad
gkabar_kad = 0
insert hha_old // HH mechanism with high threshold for Na spikes (-50 mV)
gnabar_hha_old = 0.007
gkbar_hha_old = 0.007/8.065
el_hha_old = -70
insert pas // leak conductance
}
axon {
insert hha2 // HH mechanism with low threshold for Na spikes (-57 mV)
gnabar_hha2 = .1
gkbar_hha2 = .1/5
gl_hha2 = 0
el_hha2 = -70
insert pas // leak conductance
g_pas = 1/Rm
insert km // m-type potassium current
gbar_km = 0.5*0.06
}
forsec all {
ek = -80
ena = 50
e_pas = -70
g_pas = 1/Rm
Ra = 50
// Ra = 100
// Ra = 150
cm = 1
}
}
obfunc connect2target() { localobj nc //$o1 target point process, optional $o2 returned NetCon
soma nc = new NetCon(&v(1), $o1)
nc.threshold = -10
if (numarg() == 2) { $o2 = nc } // for backward compatibility
return nc
}
objref syn_
proc synapses() {
/* E0 */ lm_thick1 syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // AMPA EC input *** DONT USE THIS ***
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E1 */ lm_thick2 syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // AMPA EC input *** DONT USE THIS ***
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E2 */ radTmed syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals *** DONT USE THIS ***
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E3 */ radTmed syn_ = new NMDA(0.5) pre_list.append(syn_) // NMDA CA3 Schaffer collaterals *** DONT USE THIS ***
syn_.tcon = 2.3
syn_.tcoff = 100
syn_.gNMDAmax = 1 // use connection weight to determine max cond
/* E4 */ radTprox syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // AMPA PC recurrent input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* I5 */ soma syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // GABA-A B cell
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I6 */ axon syn_ = new MyExp2Syn(0.1) pre_list.append(syn_) // GABA-A AA cell
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I7 */ lm_thick1 syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // GABA-A OLM cells
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I8 */ lm_thick2 syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // GABA-A OLM cells
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I9 */ lm_thick1 syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // GABA-B OLM cells
syn_.tau1 = 35
syn_.tau2 = 100
syn_.e = -75
/* I10 */ lm_thick2 syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // GABA-B OLM cells
syn_.tau1 = 35
syn_.tau2 = 100
syn_.e = -75
/* I11 */ radTmed syn_ = new MyExp2Syn(0.8) pre_list.append(syn_) // GABA-A BS cells
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I12 */ radTmed syn_ = new MyExp2Syn(0.7) pre_list.append(syn_) // GABA-A BS cells
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I13 */ radTmed syn_ = new MyExp2Syn(0.6) pre_list.append(syn_) // GABA-A BS cells
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I14 */ radTmed syn_ = new MyExp2Syn(0.4) pre_list.append(syn_) // GABA-A BS cells
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I15 */ radTmed syn_ = new MyExp2Syn(0.3) pre_list.append(syn_) // GABA-A BS cells
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I16 */ radTmed syn_ = new MyExp2Syn(0.2) pre_list.append(syn_) // GABA-A BS cells
syn_.tau1 = 1
syn_.tau2 = 8
syn_.e = -75
/* I17 */ radTmed syn_ = new MyExp2Syn(0.8) pre_list.append(syn_) // GABA-B BS cells
syn_.tau1 = 35
syn_.tau2 = 100
syn_.e = -75
/* I18 */ radTmed syn_ = new MyExp2Syn(0.7) pre_list.append(syn_) // GABA-B BS cells
syn_.tau1 = 35
syn_.tau2 = 100
syn_.e = -75
/* I19 */ radTmed syn_ = new MyExp2Syn(0.6) pre_list.append(syn_) // GABA-B BS cells
syn_.tau1 = 35
syn_.tau2 = 100
syn_.e = -75
/* I20 */ radTmed syn_ = new MyExp2Syn(0.4) pre_list.append(syn_) // GABA-B BS cells
syn_.tau1 = 35
syn_.tau2 = 100
syn_.e = -75
/* I21 */ radTmed syn_ = new MyExp2Syn(0.3) pre_list.append(syn_) // GABA-B BS cells
syn_.tau1 = 35
syn_.tau2 = 100
syn_.e = -75
/* I22 */ radTmed syn_ = new MyExp2Syn(0.2) pre_list.append(syn_) // GABA-B BS cells
syn_.tau1 = 35
syn_.tau2 = 100
syn_.e = -75
/* E23 */ lm_thick1 syn_ = new MyExp2Syn(0.1) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E24 */ lm_thick2 syn_ = new MyExp2Syn(0.1) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E25 */ lm_thick1 syn_ = new MyExp2Syn(0.2) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E26 */ lm_thick2 syn_ = new MyExp2Syn(0.2) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E27 */ lm_thick1 syn_ = new MyExp2Syn(0.3) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E28 */ lm_thick2 syn_ = new MyExp2Syn(0.3) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E29 */ lm_thick1 syn_ = new MyExp2Syn(0.4) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E30 */ lm_thick2 syn_ = new MyExp2Syn(0.4) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E31 */ lm_thick1 syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E32 */ lm_thick2 syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E33 */ lm_thick1 syn_ = new MyExp2Syn(0.6) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E34 */ lm_thick2 syn_ = new MyExp2Syn(0.6) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E35 */ lm_thick1 syn_ = new MyExp2Syn(0.7) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E36 */ lm_thick2 syn_ = new MyExp2Syn(0.7) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E37 */ lm_thick1 syn_ = new MyExp2Syn(0.8) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E38 */ lm_thick2 syn_ = new MyExp2Syn(0.8) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E39 */ lm_thick1 syn_ = new MyExp2Syn(0.9) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E40 */ lm_thick2 syn_ = new MyExp2Syn(0.9) pre_list.append(syn_) // AMPA EC input
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E41 */ radTmed syn_ = new MyExp2Syn(0.1) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E42 */ radTmed syn_ = new MyExp2Syn(0.2) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E43 */ radTmed syn_ = new MyExp2Syn(0.3) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E44 */ radTmed syn_ = new MyExp2Syn(0.4) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E45 */ radTmed syn_ = new MyExp2Syn(0.5) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E46 */ radTmed syn_ = new MyExp2Syn(0.6) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E47 */ radTmed syn_ = new MyExp2Syn(0.7) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E48 */ radTmed syn_ = new MyExp2Syn(0.8) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E49 */ radTmed syn_ = new MyExp2Syn(0.9) pre_list.append(syn_) // AMPA CA3 Schaffer collaterals
syn_.tau1 = 0.5
syn_.tau2 = 3
syn_.e = 0
/* E50 */ radTmed syn_ = new NMDA(0.2) pre_list.append(syn_) // NMDA CA3 Schaffer collaterals
syn_.tcon = 2.3
syn_.tcoff = 100
syn_.gNMDAmax = 1 // use connection weight to determine max cond
/* E51 */ radTmed syn_ = new NMDA(0.4) pre_list.append(syn_) // NMDA CA3 Schaffer collaterals
syn_.tcon = 2.3
syn_.tcoff = 100
syn_.gNMDAmax = 1 // use connection weight to determine max cond
/* E52 */ radTmed syn_ = new NMDA(0.5) pre_list.append(syn_) // NMDA CA3 Schaffer collaterals
syn_.tcon = 2.3
syn_.tcoff = 100
syn_.gNMDAmax = 1 // use connection weight to determine max cond
/* E53 */ radTmed syn_ = new NMDA(0.6) pre_list.append(syn_) // NMDA CA3 Schaffer collaterals
syn_.tcon = 2.3
syn_.tcoff = 100
syn_.gNMDAmax = 1 // use connection weight to determine max cond
/* E54 */ radTmed syn_ = new NMDA(0.8) pre_list.append(syn_) // NMDA CA3 Schaffer collaterals
syn_.tcon = 2.3
syn_.tcoff = 100
syn_.gNMDAmax = 1 // use connection weight to determine max cond
// /* E55 */ lm_thick1 syn_ = new NMDA(0.5) pre_list.append(syn_) // NMDA EC perforant path
// syn_.tcon = 2.3
// syn_.tcoff = 100
// syn_.gNMDAmax = 1 // use connection weight to determine max cond
// /* E56 */ lm_thick2 syn_ = new NMDA(0.5) pre_list.append(syn_) // NMDA EC perforant path
// syn_.tcon = 2.3
// syn_.tcoff = 100
// syn_.gNMDAmax = 1 // use connection weight to determine max cond
}
func is_art() { return 0 }
endtemplate CA1PyramidalCell
