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Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
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Accession:
185858
"Neuronal persistent activity has been primarily assessed in terms of electrical mechanisms, without attention to the complex array of molecular events that also control cell excitability. We developed a multiscale neocortical model proceeding from the molecular to the network level to assess the contributions of calcium regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in providing additional and complementary support of continuing activation in the network. ..."
Reference:
1 .
Neymotin SA, McDougal RA, Bulanova AS, Zeki M, Lakatos P, Terman D, Hines ML, Lytton WW (2016) Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex.
Neuroscience
316
:344-66
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Neuron or other electrically excitable cell;
Synapse;
Channel/Receptor;
Molecular Network;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Neocortex V1 interneuron basket PV GABA cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Neocortex layer 2-3 interneuron;
Neocortex layer 5 interneuron;
Neocortex layer 6a interneuron;
Channel(s):
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I CAN;
I Calcium;
I_AHP;
I_KD;
Ca pump;
Gap Junctions:
Receptor(s):
mGluR1;
GabaA;
GabaB;
AMPA;
NMDA;
mGluR;
Glutamate;
Gaba;
IP3;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Ion Channel Kinetics;
Oscillations;
Spatio-temporal Activity Patterns;
Signaling pathways;
Working memory;
Attractor Neural Network;
Calcium dynamics;
Laminar Connectivity;
G-protein coupled;
Rebound firing;
Brain Rhythms;
Dendritic Bistability;
Reaction-diffusion;
Beta oscillations;
Persistent activity;
Multiscale;
Implementer(s):
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
McDougal, Robert [robert.mcdougal at yale.edu];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
Neocortex V1 interneuron basket PV GABA cell
;
mGluR1
;
GabaA
;
GabaB
;
AMPA
;
NMDA
;
mGluR
;
Glutamate
;
Gaba
;
IP3
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I CAN
;
I Calcium
;
I_AHP
;
I_KD
;
Ca pump
;
Gaba
;
Glutamate
;
/
CaHDemo
readme.html
cagk.mod
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