CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:186768
This computational study investigates how a CA3 neuronal network consisting of pyramidal cells, basket cells and OLM interneurons becomes epileptic when dendritic inhibition to pyramidal cells is impaired due to the dysfunction of OLM interneurons. After standardizing the baseline activity (theta-modulated gamma oscillations), systematic changes are made in the connectivities between the neurons, as a result of step-wise impairment of dendritic inhibition.
Reference:
1 . Sanjay M, Neymotin SA, Krothapalli SB (2015) Impaired dendritic inhibition leads to epileptic activity in a computer model of CA3. Hippocampus 25:1336-50 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Activity Patterns; Oscillations; Pathophysiology; Epilepsy; Brain Rhythms;
Implementer(s): Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org]; Sanjay, M [msanjaycmc at gmail.com];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; GabaA; AMPA; NMDA;
/
SanjayEtAl2015
readme.html
CA1ih.mod *
CA1ika.mod *
CA1ikdr.mod *
CA1ina.mod *
caolmw.mod *
capr.mod *
icaolmw.mod *
icapr.mod *
iholmkop.mod *
iholmw.mod *
ihpyrkop.mod *
kahppr.mod *
kaolmkop.mod *
kapyrkop.mod *
kcaolmw.mod *
kcpr.mod *
kdrbwb.mod *
kdrolmkop.mod *
kdrpr.mod *
kdrpyrkop.mod *
misc.mod *
MyExp2Syn.mod *
MyExp2SynAlpha.mod *
MyExp2SynBB.mod *
MyExp2SynNMDA.mod *
MyExp2SynNMDABB.mod *
nafbwb.mod *
nafolmkop.mod *
nafpr.mod *
nafpyrkop.mod *
stats.mod
vecst.mod *
wrap.mod *
aux_fun.inc *
declist.hoc *
decmat.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
Epileptic Activity.png
geom.hoc *
geom.py *
grvec.hoc *
init.hoc *
labels.hoc *
local.hoc *
misc.h *
mosinit.py
network.py *
networkmsj.py
nqs.hoc *
nqs_utils.hoc *
nrnoc.hoc *
params.py
pyinit.py *
run.py
simctrl.hoc *
stats.hoc *
syncode.hoc *
xgetargs.hoc *
xtmp
                            
: $Id: CA1ikdr.mod,v 1.2 2010/12/01 05:10:52 samn Exp $ 
TITLE IKDR CA1

UNITS {
  (mA) = (milliamp)
  (mV) = (millivolt)
}
 
NEURON {
  SUFFIX kdrcurrent
  NONSPECIFIC_CURRENT ik
  RANGE g, e, ninf, ntau
}
 
PARAMETER {
  celsius	(degC)
  g = 0.010	(mho/cm2)
  e = -90	(mV)
}
 
STATE {
  n 
}
 
ASSIGNED {
  v	  (mV)
  ik	  (mA/cm2) 
  ninf
  ntau    (ms)
}

PROCEDURE iassign () { ik=g*n*(v-e) }
 
BREAKPOINT {
  SOLVE states METHOD cnexp
  iassign()
}
 
DERIVATIVE states { 
  rates(v)
  n'= (ninf- n)/ ntau
}

INITIAL { 
  rates(v)
  n = ninf
  iassign()
}

PROCEDURE rates(v (mV)) {
  LOCAL  a, b
  UNITSOFF
  a = exp(-0.11*(v-13))
  b = exp(-0.08*(v-13)) 	
  ntau=50*b/(1+a)
  if (ntau<2) {ntau=2}
  ninf=1/(1+a)
  UNITSON
}