CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)

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Accession:186768
This computational study investigates how a CA3 neuronal network consisting of pyramidal cells, basket cells and OLM interneurons becomes epileptic when dendritic inhibition to pyramidal cells is impaired due to the dysfunction of OLM interneurons. After standardizing the baseline activity (theta-modulated gamma oscillations), systematic changes are made in the connectivities between the neurons, as a result of step-wise impairment of dendritic inhibition.
Reference:
1 . Sanjay M, Neymotin SA, Krothapalli SB (2015) Impaired dendritic inhibition leads to epileptic activity in a computer model of CA3. Hippocampus 25:1336-50 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Activity Patterns; Oscillations; Pathophysiology; Epilepsy; Brain Rhythms;
Implementer(s): Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org]; Sanjay, M [msanjaycmc at gmail.com];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; GabaA; AMPA; NMDA;
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SanjayEtAl2015
readme.html
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Epileptic Activity.png
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xtmp
                            
: $Id: icapr.mod,v 1.2 2010/12/13 21:32:18 samn Exp $ 
COMMENT

//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
//
// NOTICE OF COPYRIGHT AND OWNERSHIP OF SOFTWARE
//
// Copyright 2007, The University Of Pennsylvania
// 	School of Engineering & Applied Science.
//   All rights reserved.
//   For research use only; commercial use prohibited.
//   Distribution without permission of Maciej T. Lazarewicz not permitted.
//   mlazarew@seas.upenn.edu
//
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

ENDCOMMENT


NEURON {
	SUFFIX icapr
	USEION ca WRITE ica
	RANGE gca, ica
}
	
UNITS {

	(mA) = (milliamp)
	(mV) = (millivolt)
	(mS) = (millisiemens)
}

PARAMETER {

    gca = 10  (mS/cm2)
    eca = 80  (mV)
}
    
ASSIGNED { 

    ica  (mA/cm2)    
    v    (mV)
    sinf (1)
    taus (ms)
}

STATE { s }

INITIAL { 

    rates(v)
    s  = sinf
}

BREAKPOINT {

	SOLVE states METHOD cnexp
	
	ica = (1e-3) * gca * s^2 * (v-eca)
}


DERIVATIVE states { 

    rates(v)
    s' = (sinf-s)/taus
}

PROCEDURE rates(v(mV)) { LOCAL a,b

    a = fun2(v,      5,    1.6,     -1/0.072)
    b = fun3(v,   -8.9,   0.02,     5)

    sinf = a/(a+b)
    taus = 1.0/(a+b)
}

INCLUDE "aux_fun.inc"