Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)

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Accession:189154
" ... We developed a multiscale model of primary motor cortex, ranging from molecular, up to cellular, and network levels, containing 1715 compartmental model neurons with multiple ion channels and intracellular molecular dynamics. We wired the model based on electrophysiological data obtained from mouse motor cortex circuit mapping experiments. We used the model to reproduce patterns of heightened activity seen in dystonia by applying independent random variations in parameters to identify pathological parameter sets. ..."
Reference:
1 . Neymotin SA, Dura-Bernal S, Lakatos P, Sanger TD, Lytton WW (2016) Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex. Front Pharmacol 7:157 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Molecular Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex layer 4 neuron; Neocortex layer 2-3 interneuron; Neocortex layer 4 interneuron; Neocortex layer 5 interneuron; Neocortex layer 6a interneuron;
Channel(s): I A; I h; I_SERCA; Ca pump; I K,Ca; I Calcium; I L high threshold; I T low threshold; I N; I_KD; I M; I Na,t;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; mGluR;
Gene(s): HCN1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Oscillations; Activity Patterns; Beta oscillations; Reaction-diffusion; Calcium dynamics; Pathophysiology; Multiscale;
Implementer(s): Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org]; Dura-Bernal, Salvador [salvadordura at gmail.com];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; GabaB; AMPA; mGluR; I Na,t; I L high threshold; I N; I T low threshold; I A; I M; I h; I K,Ca; I Calcium; I_SERCA; I_KD; Ca pump; Gaba; Glutamate;
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dystdemo
readme.txt
cagk.mod *
cal.mod *
calts.mod *
can.mod *
cat.mod *
gabab.mod
h_winograd.mod
HCN1.mod
IC.mod *
icalts.mod *
ihlts.mod *
kap.mod
kcalts.mod *
kdmc.mod
kdr.mod
km.mod *
mglur.mod *
misc.mod *
MyExp2SynBB.mod *
MyExp2SynNMDABB.mod
nax.mod
stats.mod *
vecst.mod *
aux_fun.inc *
conf.py
declist.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
geom.py
ghk.inc *
grvec.hoc *
init.hoc
labels.hoc *
labels.py *
local.hoc *
misc.h
mpisim.py
netcfg.cfg
nqs.hoc *
nqs.py
nrnoc.hoc *
pyinit.py *
python.hoc *
pywrap.hoc *
simctrl.hoc *
simdat.py
syn.py
syncode.hoc *
vector.py *
xgetargs.hoc *
                            
[seed]
iseed = 1234
wseed = 4321
pseed = 4321

[netsyn]
NMAMREE = 0.1
NMAMREI = 0.1
mGLURR = 6.62175993066
GB2R = 7.5
rdmsec = 1
nmfracca = 0.13

[chan]
ihginc = 2.0
iark2fctr = 1.0
iark4 = 0.008
erevh = -30.0
h_lambda = 325.0
h_gbar = 0.00292437741203
fs_h_gbar = 2.33950192963e-05
lts_h_gbar = 0.175462644722
cagk_gbar = 0.000137388040277
ikc_gkbar = 0.00212214310843
nax_gbar = 0.0910437909653
kdr_gbar = 0.0179174349495
kap_gbar = 0.306397964614
kdmc_gbar = 0.000798384403161
km_gmax = 0.139637930059
cabar = 0
lts_cabar = 0

[cada]
taur = 5

[run]
indir = data
outdir = data
tstop = 2000.0
dt = 0.1
saveout = 1
simstr = dystonia
dorun = 1
doquit = 1
dodraw = 0
verbose = 0
cvodeactive = 0
recdt = 10.0
recvdt = 1.0
binsz = 5
saveconns = 0

[rxd]
CB_frate = 5.5
CB_brate = 0.0026
CB_init = 0.2
gip3 = 120400.0
gserca = 4.0
gleak = 3.0
cacytinit = 100e-6
caerinit = 1.25
caexinit = 0.0
spaceum = 0.0
nsubseg = 0
subsegum = 0.0
v1ryr = 59.3798324743

[net]
scale = 1.0
wirety = swire
IIGain = 0.1
IEGain = 0.15
EIGainFS = 0.15
EIGainLTS = 0.15
EEGain = 0.25

[stim]
EXGain = 1.0
noise = 1
ip3_stim = 0.0
ip3_stimT = 10000.0
sgrhzNMI = 600.0
sgrhzNME = 300.0
sgrhzEE = 800.0
sgrhzEI = 1600.0
sgrhzIE = 150.0
sgrhzII = 150.0
sgrhzMGLURE = 0.0
sgrhzGB2 = 0.0