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Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
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Model Information
Model File
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Accession:
195615
"Corticospinal neurons (SPI), thick-tufted pyramidal neurons in motor cortex layer 5B that project caudally via the medullary pyramids, display distinct class-specific electrophysiological properties in vitro: strong sag with hyperpolarization, lack of adaptation, and a nearly linear frequency-current (FI) relationship. We used our electrophysiological data to produce a pair of large archives of SPI neuron computer models in two model classes: 1. Detailed models with full reconstruction; 2. Simplified models with 6 compartments. We used a PRAXIS and an evolutionary multiobjective optimization (EMO) in sequence to determine ion channel conductances. ..."
Reference:
1 .
Neymotin SA, Suter BA, Dura-Bernal S, Shepherd GM, Migliore M, Lytton WW (2017) Optimizing computer models of corticospinal neurons to replicate in vitro dynamics.
J Neurophysiol
117
:148-162
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Neocortex primary motor area pyramidal layer 5 corticospinal cell;
Channel(s):
I A;
I h;
I_KD;
I K,Ca;
I L high threshold;
I Na,t;
I N;
Ca pump;
Kir;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Parameter Fitting;
Activity Patterns;
Active Dendrites;
Detailed Neuronal Models;
Simplified Models;
Implementer(s):
Suter, Benjamin ;
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Dura-Bernal, Salvador [salvadordura at gmail.com];
Forzano, Ernie ;
Search NeuronDB
for information about:
Neocortex M1 L5B pyramidal pyramidal tract GLU cell
;
I Na,t
;
I L high threshold
;
I N
;
I A
;
I h
;
I K,Ca
;
I_KD
;
Ca pump
;
Kir
;
Download the displayed file
/
spidemo
data
readme.html
cadad.mod
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Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
kap_BS.mod
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Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
kdmc_BS.mod
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kdr_BS.mod
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misc.mod
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nax_BS.mod
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.gitattributes
archfig.py
axonMorph.py
BS0284.ASC
BS0409.ASC
conf.py
Fig6.py
figure_1.png
misc.h
morph.py
mosinit.py
PTcell.BS0284.cfg
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PTcell.BS0409.cfg
PTcell.cfg
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Other models using PTcell.cfg:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
sim.py
SPI6.cfg
SPI6.py
utils.py
exec(compile(open("Fig6.py", "rb").read(), "Fig6.py", 'exec'))
