Advanced search
User account
Login
Register
Find models by
Model name
First author
Each author
Find models for
Brain region
Concept
Find models of
Realistic Microcircuits
Connectionist Networks
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Download zip file
Auto-launch
Help downloading and running models
Model Information
Model File
Model Views
Simulation Platform
Versions
Accession:
20212
We developed a CA1 pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous dendritic and somatic recordings, and combining results for two different response measures (peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains), and two different spatial integration conditions (within vs. between-branch summation), we found the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. In addition to suggesting a new type of experiment and providing testable predictions, our model shows how conclusions regarding synaptic arithmetic can be influenced by an array of seemingly innocuous experimental design choices.
Reference:
1 .
Poirazi P, Brannon T, Mel BW (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell.
Neuron
37
:977-87
[
PubMed
]
2 .
Poirazi P, Brannon T, Mel BW (2003) Pyramidal neuron as two-layer neural network.
Neuron
37
:989-99
[
PubMed
]
3 .
Poirazi P, Brannon T, Mel BW (2003ab-sup) Online Supplement: About the Model
Neuron
37 Online
:1-20
4 .
Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells.
Nat Neurosci
7
:621-7
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
Gap Junctions:
Receptor(s):
GabaA;
GabaB;
NMDA;
Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Activity Patterns;
Dendritic Action Potentials;
Active Dendrites;
Influence of Dendritic Geometry;
Detailed Neuronal Models;
Action Potentials;
Depression;
Delay;
Implementer(s):
Poirazi, Panayiota [poirazi at imbb.forth.gr];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
GabaA
;
GabaB
;
NMDA
;
Glutamate
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
/
CA1_multi
mechanism
not-currently-used
cad.mod
*
Other models using cad.mod:
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
cagk.mod
*
Other models using cagk.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
cal.mod
*
Other models using cal.mod:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
calH.mod
*
Other models using calH.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
car.mod
*
Other models using car.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
cat.mod
*
Other models using cat.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
d3.mod
*
Other models using d3.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
gabaa.mod
*
Other models using gabaa.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
gabab.mod
*
Other models using gabab.mod:
Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
glutamate.mod
*
Other models using glutamate.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
h.mod
*
Other models using h.mod:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
MEG of Somatosensory Neocortex (Jones et al. 2007)
hha_old.mod
*
Other models using hha_old.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
hha2.mod
*
Other models using hha2.mod:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
kadist.mod
*
Other models using kadist.mod:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
kaprox.mod
*
Other models using kaprox.mod:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
kca.mod
*
Other models using kca.mod:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
km.mod
*
Other models using km.mod:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009)
nap.mod
*
Other models using nap.mod:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
nmda.mod
*
Other models using nmda.mod:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
somacar.mod
*
Other models using somacar.mod:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
mosinit.hoc
*
Other models using mosinit.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
mosinit.hoc.old
*
Other models using mosinit.hoc.old:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
File not selected
<- Select file from this column.
Load Model Views
Disperse 6_2
Simulation Platform