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CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
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Accession:
20212
We developed a CA1 pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous dendritic and somatic recordings, and combining results for two different response measures (peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains), and two different spatial integration conditions (within vs. between-branch summation), we found the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. In addition to suggesting a new type of experiment and providing testable predictions, our model shows how conclusions regarding synaptic arithmetic can be influenced by an array of seemingly innocuous experimental design choices.
Reference:
1 .
Poirazi P, Brannon T, Mel BW (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell.
Neuron
37
:977-87
[
PubMed
]
2 .
Poirazi P, Brannon T, Mel BW (2003) Pyramidal neuron as two-layer neural network.
Neuron
37
:989-99
[
PubMed
]
3 .
Poirazi P, Brannon T, Mel BW (2003ab-sup) Online Supplement: About the Model
Neuron
37 Online
:1-20
4 .
Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells.
Nat Neurosci
7
:621-7
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
Gap Junctions:
Receptor(s):
GabaA;
GabaB;
NMDA;
Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Activity Patterns;
Dendritic Action Potentials;
Active Dendrites;
Influence of Dendritic Geometry;
Detailed Neuronal Models;
Action Potentials;
Depression;
Delay;
Implementer(s):
Poirazi, Panayiota [poirazi at imbb.forth.gr];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
GabaA
;
GabaB
;
NMDA
;
Glutamate
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
Download the displayed file
/
CA1_multi
lib
basic_graphics.hoc
*
Other models using basic_graphics.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
basic-graphics.hoc
*
Other models using basic-graphics.hoc:
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Fast Spiking Basket cells (Tzilivaki et al 2019)
L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
choose-secs.hoc
*
Other models using choose-secs.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
current-balance.hoc
*
Other models using current-balance.hoc:
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
cut-sections.hoc
*
Other models using cut-sections.hoc:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
deduce-ratio.hoc
*
Other models using deduce-ratio.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
find-gmax.hoc
*
Other models using find-gmax.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
GABA_shiftsyn.hoc
*
Other models using GABA_shiftsyn.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
GABA_shiftsyn_bg.hoc
*
Other models using GABA_shiftsyn_bg.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
ken.h
*
Other models using ken.h:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
map-segments-to-3d.hoc
*
Other models using map-segments-to-3d.hoc:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
maxmin.hoc
*
Other models using maxmin.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
mod_func.c
*
Other models using mod_func.c:
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
newshiftsyn.c
*
Other models using newshiftsyn.c:
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
newshiftsyn.exe
*
Other models using newshiftsyn.exe:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
num-rec.h
*
Other models using num-rec.h:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
salloc.hoc
*
Other models using salloc.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
shiftsyn-init_bg.hoc
*
Other models using shiftsyn-init_bg.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
shiftsyn-initA.hoc
*
Other models using shiftsyn-initA.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
shiftsyn-initA.hoc~
*
Other models using shiftsyn-initA.hoc~:
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
spikecount.hoc
*
Other models using spikecount.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
tune-epsps.hoc
*
Other models using tune-epsps.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
vector-distance.hoc
*
Other models using vector-distance.hoc:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
verbose-system.hoc
*
Other models using verbose-system.hoc:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
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