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CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
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Accession:
206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 .
Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time.
Neuron
87
:576-89
[
PubMed
]
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Model Information
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Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Calcium;
I Sodium;
I Potassium;
I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Gaba;
Simulation Environment:
NEURON;
Model Concept(s):
Action Potentials;
Dendritic Action Potentials;
Active Dendrites;
Calcium dynamics;
Implementer(s):
Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
I h
;
I Sodium
;
I Calcium
;
I Potassium
;
Gaba
;
/
CA1_multi
template
BasalPath.hoc
*
Other models using BasalPath.hoc:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
ExperimentControl.hoc
*
Other models using ExperimentControl.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
load_templates.hoc
ObliquePath.hoc
*
Other models using ObliquePath.hoc:
Active dendrites shape signaling microdomains in hippocampal neurons (Basak & Narayanan 2018)
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Chirp stimulus responses in a morphologically realistic model (Narayanan and Johnston, 2007)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
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