Model of memory linking through memory allocation (Kastellakis et al. 2016)

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Accession:206249
Here, we present a simplified, biophysically inspired network model that incorporates multiple plasticity processes and explains linking of information at three different levels: (a) learning of a single associative memory (b) rescuing of a weak memory when paired with a strong one and (c) linking of multiple memories across time. By dissecting synaptic from intrinsic plasticity and neuron-wide from dendritically restricted protein capture, the model reveals a simple, unifying principle: Linked memories share synaptic clusters within the dendrites of overlapping populations of neurons
Reference:
1 . Kastellakis G, Silva AJ, Poirazi P (2016) Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites. Cell Rep 17:1491-1504 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Abstract integrate-and-fire leaky neuron with dendritic subunits;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program; C or C++ program (web link to model);
Model Concept(s): Active Dendrites;
Implementer(s): Kastellakis, George [gkastel at gmail.com];
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allgraphs.m
allrun.m
an_brtest.m
an_stats.m
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barwitherr.m *
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constructs.cpp
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graphs.m *
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intexp_constructs.cpp
job_sims.sh
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lamodel.cpp
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multi.py
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run_1.sh
run_2strong.sh
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run_all.sh
run_brov.sh
run_brtest.sh
run_btag.sh
run_dir.sh
run_ep.sh
run_gp.sh
run_gp2.sh
run_mult.sh
run_Nsparse.sh
run_pairstrong.sh
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function la_run {
	qsub -v "LAPARAMS=$LAPARAMS" submit_lamodel.sh
	#echo ./lamodel $LAPARAMS 
	#./lamodel $LAPARAMS &
}



for run in 0 1 2 3 4 5 6 7 8 9
do
	for ParamVal in 0.7 0.8 0.9 1.0 1.1 1.2 1.3
	do

		for ParamName in CREBTimeParam connectivityParam inhibitionParam initWeight maxWeight dendSpikeThresh globalPRPThresh localPRPThresh homeostasisTimeParam nNeuronsParam nBranchesParam
		do

			#LAPARAMS=" -P 1 -T 180 -S 1980$run -s NPERT_${ParamName}_${ParamVal}_${run} -o connectivityParam=2.363 -o dendSpikeThresh=3.0  -o ${ParamName}=${ParamVal}"

			LAPARAMS=" -P 1 -T 180 -S 1980$run -s PERT_${ParamName}_${ParamVal}_${run}   -o ${ParamName}=${ParamVal}"
			la_run

			LAPARAMS=" -P 1 -T 180 -S 1980$run -s PERTL_${ParamName}_${ParamVal}_${run}  -o ${ParamName}=${ParamVal} -L"
			la_run

			LAPARAMS=" -P 1 -T 180 -S 1980$run -s PERTG_${ParamName}_${ParamVal}_${run}  -o ${ParamName}=${ParamVal} -G"
			la_run

			LAPARAMS=" -w 2 -P 2 -T 60 -S 1980$run -s PERTWS_${ParamName}_${ParamVal}_${run}  -o ${ParamName}=${ParamVal} "
			la_run

			LAPARAMS=" -w 2 -P 2 -T 60 -S 1980$run -s PERTWSG_${ParamName}_${ParamVal}_${run}   -o ${ParamName}=${ParamVal} -G"
			la_run

			LAPARAMS=" -w 2 -P 2 -T 60 -S 1980$run -s PERTWSL_${ParamName}_${ParamVal}_${run}  -o ${ParamName}=${ParamVal} -L"
			la_run
		done
	done
done