" ... We hypothesized that currents are grouped into distinct
modules that shape specific neuronal characteristics or signatures,
such as resting potential, sub-threshold oscillations,
and spiking waveforms, for several classes of
neurons. For such a grouping to occur, the currents within
one module should have minimal functional interference
with currents belonging to other modules. This condition
is satisfied if the gating functions of currents in the same
module are grouped together on the voltage axis; in contrast,
such functions are segregated along the voltage axis
for currents belonging to different modules. We tested this
hypothesis using four published example case models and
found it to be valid for these classes of neurons. ..."
Reference:
1 .
Alturki A, Feng F, Nair A, Guntu V, Nair SS (2016) Distinct current modules shape cellular dynamics in model neurons. Neuroscience 334:309-331 [PubMed]
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