2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)

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Accession:232097
This is a biophysical model of the olfactory bulb (OB) that contains three types of neurons: mitral cells, granule cells and periglomerular cells. The model is used to study the cellular and synaptic mechanisms of OB gamma oscillations. We concluded that OB gamma oscillations can be best modeled by the coupled oscillator architecture termed pyramidal resonance inhibition network gamma (PRING).
Reference:
1 . Li G, Cleland TA (2017) A coupled-oscillator model of olfactory bulb gamma oscillations. PLoS Comput Biol 13:e1005760 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron periglomerular GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Olfaction;
Implementer(s): Li, Guoshi [guoshi_li at med.unc.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell; GabaA; AMPA; NMDA;
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OBGAMMA
data0
README
cadecay.mod *
cadecay2.mod *
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Can.mod *
CaPN.mod *
CaT.mod *
GradeAMPA.mod *
GradeGABA.mod *
GradNMDA.mod *
hpg.mod *
kAmt.mod *
KCa.mod *
KDRmt.mod *
kfasttab.mod *
kM.mod *
KS.mod
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LCa.mod *
nafast.mod *
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Nicotin.mod *
nmdanet.mod *
OdorInput.mod *
SineInput.mod
Background.hoc
Cal_Synch.hoc
Connect.hoc
Figure.hoc
GC_def.hoc
GC_save.hoc *
GC_Stim.hoc
Input.hoc
mathslib.hoc
MC_def.hoc
MC_save.hoc
MC_Stim.hoc
mosinit.hoc
OBNet.hoc
Parameter.hoc
PG_def.hoc
PG_save.hoc *
PG_Stim.hoc
SaveData.hoc
tabchannels.dat *
tabchannels.hoc
                            
TITLE HH slow potassium channel with FUNCTION_TABLEs
: Hodgkin - Huxley potassium channel using the data given in
: US Bhalla and JM Bower, J. Neurophysiol. 69:1948-1983 (1993)
: Needs the files tabchannels.dat and tabchannels.hoc
: Andrew Davison, The Babraham Institute, 1998.


NEURON {
	SUFFIX kslowtab
	USEION k READ ek WRITE ik
	RANGE gkbar, ik
	GLOBAL ninf, kinf, ntau, ktau
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {
	v (mV)
	dt (ms)
	gkbar= 0.120 (mho/cm2) <0,1e9>
	ek = -70 (mV)
}
STATE {
	n k
}
ASSIGNED {
	ik (mA/cm2)
	ninf
	kinf
	ntau (ms)
	ktau (ms)
}

INITIAL {
	rates(v)
	n = ninf
	k = kinf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	ik = gkbar*n*n*k*(v - ek)
}

DERIVATIVE states {
	rates(v)
	n' = (ninf - n)/ntau
	k' = (kinf - k)/ktau
}

FUNCTION_TABLE tabninf(v(mV))
FUNCTION_TABLE tabntau(v(mV)) (ms)
FUNCTION_TABLE tabkinf(v(mV))
FUNCTION_TABLE tabktau(v(mV)) (ms)

PROCEDURE rates(v(mV)) {
	ninf = tabninf(v)
	ntau = tabntau(v) 
	kinf = tabkinf(v)
	ktau = tabktau(v)
}