Cortical feedback alters visual response properties of dLGN relay cells (Martínez-Cañada et al 2018)

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Network model that includes biophysically detailed, single-compartment and multicompartment neuron models of relay-cells and interneurons in the dLGN and a population of orientation-selective layer 6 simple cells, consisting of pyramidal cells (PY). We have considered two different arrangements of synaptic feedback from the ON and OFF zones in the visual cortex to the dLGN: phase-reversed (‘push-pull’) and phase-matched (‘push-push’), as well as different spatial extents of the corticothalamic projection pattern. This project is the result of a research work and its associated publication is: (Martínez-Cañada et al 2018). Installation instructions as well as the latest version can be found in the Github repository:
1 . Martínez-Cañada P, Mobarhan MH, Halnes G, Fyhn M, Morillas C, Pelayo F, Einevoll GT (2018) Biophysical network modeling of the dLGN circuit: Effects of cortical feedback on spatial response properties of relay cells. PLoS Comput Biol 14:e1005930 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s):
Gap Junctions:
Simulation Environment: LFPy; NEURON; NEST; Python;
Model Concept(s): Vision;
Implementer(s): Martínez-Cañada, Pablo [pablomc at];
cadecay.mod *
IM.mod *
IT.mod *
demo_IN_FS.oc *
demo_PY_LTS.oc *
demo_PY_RS.oc *
mosinit.hoc *
rundemo.hoc *
soma.hoc *

                          Alain Destexhe

            CNRS, UNIC (Bat-33), Avenue de la Terrasse,
                 91198 Gif-sur-Yvette, France


This package is running with the NEURON simulation program written by Michael
Hines and available on internet at:

The package contains mechanisms (.mod files) and programs (.oc files) needed to
simulate single-compartment models of cortical neurons.  Details of the
kinetics of currents are given in:

  Destexhe A and Sejnowski TJ.  Thalamocortical Assemblies.
  Oxford University Press, 2001

See also the original paper:

  Destexhe A, Contreras D and Steriade M.  Mechanisms underlying the 
  synchronizing action of corticothalamic feedback through inhibition of 
  thalamic relay cells. J. Neurophysiol. 79: 999-1016, 1998.

  Destexhe A, Contreras D and Steriade M.  LTS cells in cerebral cortex
  and their role in generating spike-and-wave oscillations.   
  Neurocomputing 38: 555-563, 2001.

(see electronic copy at


demo_PY_RS.oc  : regular-spiking pyramidal neuron
demo_PY_LTS.oc : bursting pyramidal neuron (LTS cell)
demo_IN_FS.oc  : fast-spiking interneuron


 HH2.mod		: fast sodium spikes (Na and K currents)
 IM.mod 		: slow voltage-dependent potassium current (IM)
 IT.mod 		: T-type calcium current
 cadecay.mod		: intracellular calcium dynamics


Use autolaunch on modeldb or:

unix platform:

To compile the demo, NEURON and INTERVIEWS must be installed and working on
the machine you are using.  Just type "nrnivmodl" to compile the mechanisms
given in the mod files.

Then, execute the main demo program by typing:

  nrngui mosinit.hoc

mswin platform:

  Compile the mechanism (mod) files by using mknrndll.  Then start the simulation
  by clicking on mosinit.hoc in windows explorer.

back to any platform:

Once the menu and graphics interface has appeared, select a simulation from the
"Simulations of cortical cells" window.  Reposition the windows to find the
Run Control window.   Then click on "Init and Run" button to start the simulation...

For more information about how to get NEURON and how to install it, please
refer to the following sites:

For further information, please contact:

Alain Destexhe

CNRS, UNIC (Bat-33), 
Avenue de la Terrasse,
91198 Gif-sur-Yvette, 


7/11/2005 Changes added which removes electrode on subsequent simulations.
Note: 3/9/2002 Michael Hines made non-substantive changes to allow the
3 demos to run in the same NEURON process. Thus the original button panel
was replaced by a radio button panel, and any files which should only
be opened once per NEURON launch are now opened via load_file instead
of xopen. Lastly, before the gui for each demo is started the previous
gui is erased with the restart() procedure which was added to

20120109 updated SOLVE method in cadecay.mod to derivimplicit and IM.mod,
IT.mod to cnexp as per