Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)

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Accession:241165
This archive instantiates the single-cell cortical models used in (Aberra et al. 2018) and sets up extracellular stimulation with either a point-current source, to simulate intracortical microstimulation (ICMS), or a uniform E-field distribution, with a monophasic, rectangular pulse waveform in both cases.
Reference:
1 . Aberra AS, Peterchev AV, Grill WM (2018) Biophysically realistic neuron models for simulation of cortical stimulation. J Neural Eng 15:066023 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism: Neocortex; Barrel cortex;
Cell Type(s): Myelinated neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models;
Implementer(s): Aberra, Aman [aman.aberra at duke.edu];
/
AberraEtAl2018
cells
L23_PC_cADpyr229_3
mechanisms
morphology
synapses
README *
.provenance.json
biophysics.hoc *
cellinfo.json *
CHANGELOG *
constants.hoc *
creategui.hoc *
createsimulation.hoc *
current_amps.dat *
init.hoc *
LICENSE *
morphology.hoc *
mosinit.hoc *
ringplot.hoc *
run.py *
run_hoc.sh *
run_py.sh *
run_RmpRiTau.py *
run_RmpRiTau_py.sh *
template.hoc
VERSION *
                            
/*                                                                               
Copyright (c) 2015 EPFL-BBP, All rights reserved.                                
                                                                                 
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WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE             
OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN           
IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.                                    
                                                                                 
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode or send a letter to Creative Commons, 171
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*/ 

/*                                                                               
 * @file createsimulation.hoc                                                           
 * @brief Set up the simulation                                
 * @author Werner Van Geit @ BBP                                                 
 * @date 2015                                                                    
*/        

load_file("nrngui.hoc")
load_file("import3d.hoc")

load_file("morphology.hoc")
load_file("biophysics.hoc")
load_file("template.hoc")

//======================== settings ===================================

hyp_amp = -0.072632
step_amp1 = 0.156774
step_amp2 = 0.1698385
step_amp3 = 0.182903

//=================== creating cell object ===========================
objref cell

proc create_cell() { local synapses_enabled
    synapses_enabled = $1
    cell = new cADpyr229_L23_PC_863902f300(synapses_enabled)
}
//==================== recording settings ==========================

objref time, voltage
proc create_recording() {
    voltage = new Vector()
    time = new Vector()

    access cell.soma
    time.record(&t, 0.1)
    voltage.record(&v(0.5), 0.1)

}

//==================== stimulus settings ===========================

objref hypamp_stimulus
objref step_stimulus

proc create_stimulus() {
    strdef stepcurrent 
    stepcurrent = $s1
    hypamp_stimulus = new IClamp(0.5)
    hypamp_stimulus.dur = tstop
    hypamp_stimulus.del = 0

    cell.soma hypamp_stimulus

    step_stimulus = new IClamp(0.5)
    step_stimulus.dur = 2000
    step_stimulus.del = 700
    if (strcmp(stepcurrent, "stepcurrent1") == 0) { 
        step_stimulus.amp = step_amp1
        hypamp_stimulus.amp = hyp_amp
    } else if (strcmp(stepcurrent, "stepcurrent2") == 0) {
        step_stimulus.amp = step_amp2
        hypamp_stimulus.amp = hyp_amp
    } else if (strcmp(stepcurrent, "stepcurrent3") == 0) {
        step_stimulus.amp = step_amp3
        hypamp_stimulus.amp = hyp_amp
    } else {
        step_stimulus.amp = 0.0
        hypamp_stimulus.amp = 0.0
    }

    cell.soma step_stimulus
}

//============================= simulation ================================

proc simulate() {
    cvode.active(0)

    run()
}

//============================= saving results ============================

proc save_recording() { localobj timevoltage, fh
    timevoltage = new Matrix(time.size(), 2)
    timevoltage.setcol(0, time)
    timevoltage.setcol(1, voltage)

    fh = new File()
    fh.wopen("hoc_recordings/soma_voltage.dat")
    timevoltage.fprint(0, fh, "%e ")
    fh.close()
}