Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation (Luque et al 2019)

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Accession:256140
"Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses. Here, a spiking cerebellar model assesses the role of Purkinje cell firing patterns in vestibular ocular reflex (VOR) adaptation. The model captures the cerebellar microcircuit properties and it incorporates spike-based synaptic plasticity at multiple cerebellar sites. ..."
Reference:
1 . Luque NR, Naveros F, Carrillo RR, Ros E, Arleo A (2019) Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS Comput Biol 15:e1006298 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum interneuron granule GLU cell; Vestibular neuron; Abstract integrate-and-fire leaky neuron;
Channel(s): I K; I Na,t; I L high threshold; I M;
Gap Junctions:
Receptor(s): AMPA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: EDLUT; NEURON; MATLAB;
Model Concept(s): Activity Patterns; Sleep; Long-term Synaptic Plasticity; Vestibular;
Implementer(s): Luque, Niceto R. [nluque at ugr.es];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; Cerebellum interneuron granule GLU cell; AMPA; Gaba; I Na,t; I L high threshold; I K; I M;
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LuqueEtAl2019
EDLUT
Articulo purkinje
CASE_A
include
spike
EDLUTException.h *
EDLUTFileException.h *
InputSpike.h *
InputSpikeGroupe.h *
Interconnection.h *
InternalSpike.h *
Network.h *
Neuron.h *
NeuronModelPropagationDelayStructure.h *
NeuronPropagationDelayStructure.h *
PropagatedSpike.h *
Spike.h *
TableBasedModelHFEvent.h *
TimeDrivenInternalSpike.h *
TimeDrivenPropagatedSpike.h *
                            
/***************************************************************************
 *                           EDLUTException.h                              *
 *                           -------------------                           *
 * copyright            : (C) 2009 by Jesus Garrido and Richard Carrillo   *
 * email                : jgarrido@atc.ugr.es                              *
 ***************************************************************************/

/***************************************************************************
 *                                                                         *
 *   This program is free software; you can redistribute it and/or modify  *
 *   it under the terms of the GNU General Public License as published by  *
 *   the Free Software Foundation; either version 3 of the License, or     *
 *   (at your option) any later version.                                   *
 *                                                                         *
 ***************************************************************************/

#ifndef EDLUTEXCEPTION_H_
#define EDLUTEXCEPTION_H_

/*!
 * \file EDLUTException.h
 *
 * \author Jesus Garrido
 * \author Richard Carrido
 * \date August 2008
 *
 * This file declares a class which abstracts an exception in the EDLUT simulation process.
 */

#include <cstdlib>
#include <cstdio>
#include <iostream>

using namespace std;

/*!
 * \class EDLUTException
 *
 * \brief Exception in the simulation process.
 *
 * This class abstract the behaviour of an exception in the EDLUT simulation process. This exception
 * could happen by different reasons (not found files, bad input spikes, not enough memory...). When
 * an exception is thrown, the simulation is stopped without results.
 *
 * \author Jesus Garrido
 * \author Richard Carrillo
 * \date August 2008
 */
class EDLUTException {
	
	private:
		/*!
		 * Number of error.
		 */
		int ErrorNum;
		
		/*!
		 * \brief It gets an only long number from four integer values.
		 * 
		 * It gets an only long number from four integer values.
		 * 
		 * \param a The most significant integer. Task number.
		 * \param b The second most significant integer. Error number.
		 * \param c The third most significant integer. Repair number.
		 * \param d The less significant integer.
		 * 
		 * \return The error value from the four integer values.
		 */
		long GetErrorValue(int a, int b, int c, int d);
		
		/*!
		 * Task messages.
		 */
		static const char * Taskmsgs[];

		/*!
		 * Error messages.
		 */
		static const char *Errormsgs[];

		/*!
		 * Repair messages.
		 */
		static const char *Repairmsgs[];
		
		
	public:
	
		/*!
		 * \brief Class constructor.
		 * 
		 * Class constructor with parameters.
		 * 
		 * \param a The most significant integer. Task number.
		 * \param b The second most significant integer. Error number.
		 * \param c The third most significant integer. Repair number.
		 * \param d The less significant integer.
		 */ 
		EDLUTException(int a, int b, int c, int d);
		
		/*!
		 * \brief It gets the error number.
		 * 
		 * It gets the error number.
		 * 
		 * \return The error number.
		 */ 
		long GetErrorNum() const;
		
		/*!
		 * \brief It gets the task message.
		 * 
		 * It gets the task that threw the error.
		 * 
		 * \return The task message.
		 */
		const char * GetTaskMsg() const;
		
		/*!
		 * \brief It gets the error message.
		 * 
		 * It gets the error message.
		 * 
		 * \return The error message.
		 */
		const char * GetErrorMsg() const;
		
		/*!
		 * \brief It gets the repair message.
		 * 
		 * It gets the repair message.
		 * 
		 * \return The repair message.
		 */
		const char * GetRepairMsg() const;
		
		/*!
		 * \brief It prints in the standard error the error message of this exception.
		 * 
		 * It prints in the standard error the error message of this exception.
		 */
		void display_error() const;
		
};

/*!
 * \brief It prints the error message of this exception.
 * 
 * It prints the error message of this exception.
 * 
 * \param out The output stream where the message is printed.
 * \param Exception The exception to be printed.
 * 
 * \return The output stream.
 */
ostream & operator<< (ostream & out, EDLUTException Exception);

#endif /*EDLUTEXCEPTION_H_*/