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Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
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Model Information
Model File
Accession:
261624
Parkinson disease (PD) is characterized by a clear beneficial motor response to levodopa (LD) treatment. However, with disease progression and longer LD exposure, drug-related motor fluctuations usually occur. Recognition of the individual relationship between LD concentration and its effect may be difficult, due to the complexity and variability of the mechanisms involved. This work proposes an innovative procedure for the automatic estimation of LD pharmacokinetics and pharmacodynamics parameters, by a biologically-inspired mathematical model. An original issue, compared with previous similar studies, is that the model comprises not only a compartmental description of LD pharmacokinetics in plasma and its effect on the striatal neurons, but also a neurocomputational model of basal ganglia action selection. Parameter estimation was achieved on 26 patients (13 with stable and 13 with fluctuating LD response) to mimic plasma LD concentration and alternate finger tapping frequency along four hours after LD administration, automatically minimizing a cost function of the difference between simulated and clinical data points. Results show that individual data can be satisfactorily simulated in all patients and that significant differences exist in the estimated parameters between the two groups. Specifically, the drug removal rate from the effect compartment, and the Hill coefficient of the concentration-effect relationship were significantly higher in the fluctuating than in the stable group. The model, with individualized parameters, may be used to reach a deeper comprehension of the PD mechanisms, mimic the effect of medication, and, based on the predicted neural responses, plan the correct management and design innovative therapeutic procedures.
Reference:
1 .
Ursino M, Magosso E, Lopane G, Calandra-Buonaura G, Cortelli P, Contin M (2020) Mathematical modeling and parameter estimation of levodopa motor response in patients with parkinson disease.
PLoS One
15
:e0229729
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Connectionist Network;
Brain Region(s)/Organism:
Basal ganglia;
Cell Type(s):
Abstract rate-based neuron;
Channel(s):
Gap Junctions:
Receptor(s):
D1;
D2;
Gene(s):
Transmitter(s):
Dopamine;
Acetylcholine;
Simulation Environment:
MATLAB;
Model Concept(s):
Parkinson's;
Parameter Fitting;
Hebbian plasticity;
Reinforcement Learning;
Implementer(s):
Ursino, Mauro [mauro.ursino at unibo.it];
Magosso, Elisa [elisa.magosso at unibo.it];
Search NeuronDB
for information about:
D1
;
D2
;
Acetylcholine
;
Dopamine
;
Download the displayed file
/
Final programs
graphic
BG_model_function_tapping_mauro_3.m
*
Other models using BG_model_function_tapping_mauro_3.m:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
Generic_patient.m
parametri_pazienteG1S1_max.mat
*
Other models using parametri_pazienteG1S1_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S10_max.mat
*
Other models using parametri_pazienteG1S10_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S11_max.mat
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Other models using parametri_pazienteG1S11_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S13_max.mat
*
Other models using parametri_pazienteG1S13_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S14_max.mat
*
Other models using parametri_pazienteG1S14_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S2_max.mat
*
Other models using parametri_pazienteG1S2_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S3_max.mat
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Other models using parametri_pazienteG1S3_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S4_max.mat
*
Other models using parametri_pazienteG1S4_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S5_max.mat
*
Other models using parametri_pazienteG1S5_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S6_max.mat
*
Other models using parametri_pazienteG1S6_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S7_max.mat
*
Other models using parametri_pazienteG1S7_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S8_max.mat
*
Other models using parametri_pazienteG1S8_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG1S9_max.mat
*
Other models using parametri_pazienteG1S9_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S1_max.mat
*
Other models using parametri_pazienteG2S1_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S10_max.mat
*
Other models using parametri_pazienteG2S10_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S11_max.mat
*
Other models using parametri_pazienteG2S11_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S12_max.mat
*
Other models using parametri_pazienteG2S12_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S13_max.mat
*
Other models using parametri_pazienteG2S13_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S2_max.mat
*
Other models using parametri_pazienteG2S2_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S3_max.mat
*
Other models using parametri_pazienteG2S3_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S4_max.mat
*
Other models using parametri_pazienteG2S4_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S5_max.mat
*
Other models using parametri_pazienteG2S5_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S6_max.mat
*
Other models using parametri_pazienteG2S6_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S7_max.mat
*
Other models using parametri_pazienteG2S7_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S8_max.mat
*
Other models using parametri_pazienteG2S8_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
parametri_pazienteG2S9_max.mat
*
Other models using parametri_pazienteG2S9_max.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S1.mat
*
Other models using pazienteG1S1.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S10.mat
*
Other models using pazienteG1S10.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S11.mat
*
Other models using pazienteG1S11.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S13.mat
*
Other models using pazienteG1S13.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S14.mat
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Other models using pazienteG1S14.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S2.mat
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Other models using pazienteG1S2.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S3.mat
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Other models using pazienteG1S3.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S4.mat
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Other models using pazienteG1S4.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S5.mat
*
Other models using pazienteG1S5.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S6.mat
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Other models using pazienteG1S6.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S7.mat
*
Other models using pazienteG1S7.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S8.mat
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Other models using pazienteG1S8.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG1S9.mat
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Other models using pazienteG1S9.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S1.mat
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Other models using pazienteG2S1.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S10.mat
*
Other models using pazienteG2S10.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S11.mat
*
Other models using pazienteG2S11.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S12.mat
*
Other models using pazienteG2S12.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S13.mat
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Other models using pazienteG2S13.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S2.mat
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Other models using pazienteG2S2.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S3.mat
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Other models using pazienteG2S3.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S4.mat
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Other models using pazienteG2S4.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S5.mat
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Other models using pazienteG2S5.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S6.mat
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Other models using pazienteG2S6.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S7.mat
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Other models using pazienteG2S7.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S8.mat
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Other models using pazienteG2S8.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
pazienteG2S9.mat
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Other models using pazienteG2S9.mat:
Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
W_tot_new_W0e5_D1e0.mat
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Other models using W_tot_new_W0e5_D1e0.mat:
A basal ganglia model of aberrant learning (Ursino et al. 2018)
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