Library of biophysically detailed striatal projection neurons (Lindroos and Hellgren Kotaleski 2020)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:266775
Library of compartmentalized models used to investigate dendritic integration in striatal projection neurons under neuromodulation.
Reference:
1 . Lindroos R, Hellgren Kotaleski J (2020) Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine. Eur J Neurosci [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Striatum; Hippocampus; Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Striatal projection neuron;
Channel(s): I M; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Acetylcholine; Dopamine;
Simulation Environment: NEURON; Python;
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Neuromodulation; Synaptic Plasticity; Activity Patterns; Soma-dendrite cross-talk;
Implementer(s): Lindroos, Robert [robert.lindroos at ki.se]; Filipovic, Marko;
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; I M; I Potassium; Acetylcholine; Dopamine; 
# striatal_SPN_lib

This repository contains a library of striatal projection neurons used in the publication:

Lindroos and Hellgren Kotaleski 2020. 
Predicting complex spikes in striatal projection neurons of the direct pathway 
following neuromodulation by acetylcholine and dopamine. EJN

Code for simulating, analysing and plotting can be found here:
https://github.com/robban80/striatal_SPN_lib
and here:
https://bitbucket.org/rlindroos/neuron/src/cholinergic_modulation/Complex_spike/


The models are built in NEURON+python 
https://www.neuron.yale.edu/neuron/


How to run the models
---------------------

1. install NEURON with python support
2. compile the mechanisms in mechanisms/single (nrnivmodl or mknrndll)
3. execute `python example.py`