Library of biophysically detailed striatal projection neurons (Lindroos and Hellgren Kotaleski 2020)

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Accession:266775
Library of compartmentalized models used to investigate dendritic integration in striatal projection neurons under neuromodulation.
Reference:
1 . Lindroos R, Hellgren Kotaleski J (2020) Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine. Eur J Neurosci [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Striatum; Hippocampus; Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Striatal projection neuron;
Channel(s): I M; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Acetylcholine; Dopamine;
Simulation Environment: NEURON; Python;
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Neuromodulation; Synaptic Plasticity; Activity Patterns; Soma-dendrite cross-talk;
Implementer(s): Lindroos, Robert [robert.lindroos at ki.se]; Filipovic, Marko;
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; I M; I Potassium; Acetylcholine; Dopamine; 
{
    "g_pas_all": 	    { "Value": " 1.25e-5 " },
    "gbar_naf_somatic": { "Value": " 12 " },
    "gbar_naf_basal": 	{ "Value": " 0.9 " },
    "gbar_naf_axonal": 	{ "Value": " 9 " },
    "gbar_kaf_somatic": { "Value": " 0.08 ", "Comment": " 0.15 in the dMSN "},
    "gbar_kaf_basal": 	{ "Value": " 0.08 ", "Comment": " 0.11 in the dMSN " },
    "gbar_kas_somatic": { "Value": " 0.016 " },
    "gbar_kas_basal": 	{ "Value": " 0.012 ", "Comment": " increased factor 10 after reducing distribution by same factor "},
    "gbar_kas_axonal": 	{ "Value": " 0.007 ", "Comment": " 0.005 "},
    "gbar_kdr_somatic": { "Value": " 0.00094 " },
    "gbar_kdr_basal": 	{ "Value": " 0.0007 " },
    "gbar_kir_somatic": { "Value": " 0.0012 " },
    "gbar_kir_basal": 	{ "Value": " 0.0012 ", "Comment": 0.0009},
    "gbar_sk_somatic": 	{ "Value": " 0.00002 " },
    "gbar_sk_basal": 	{ "Value": " 0.00002 ", "Comment": " both sk and bk are lower since [Ca]_i is higher in Alex latest version " },
    "gbar_bk_somatic": 	{ "Value": " 0.00013 " },
    "gbar_bk_basal": 	{ "Value": " 0.0001 " }
}