Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)

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Accession:266823
"... we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. These computational experiments demonstrated that glutamatergic co-stimulation enhances GABA receptor-mediated Cl- influx at low and attenuates or reverses the Cl- efflux at high initial [Cl-]i. The size of glutamatergic influence on GABAergic Cl--fluxes depends on the conductance, decay kinetics, and localization of glutamatergic inputs. Surprisingly, the glutamatergic shift in GABAergic Cl--fluxes is invariant to latencies between GABAergic and glutamatergic inputs over a substantial interval..."
Reference:
1 . Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2021) Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons PLOS Comp Bio
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Short-term Synaptic Plasticity; Synaptic Plasticity; Chloride regulation;
Implementer(s): Jedlicka, Peter [jedlicka at em.uni-frankfurt.de]; Kilb, Werner [wkilb at uni-mainz.de];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
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_For Zip -Neuron-Models_AMPA-GABA
Fig7cd_Real_Cell_GDP_one for display
cldif_CA3_NKCC1_HCO3.mod *
gabaA_Cl_HCO3.mod *
vecevent.mod *
Cell1_Cl_HCO3_Pas_Fine.hoc
GDP_Cl_All_short.ses
Single_GDP_gGABA-0.789-nGABA-534_Fix_gAMPA_Fix_Cl.hoc
Single_GDP_gGABA-0.789-nGABA-534_VDpas_Div_gAMPA_Div_Cl.hoc
start_Single_GDP_gGABA-0.789-nGABA-534_Fix_gAMPA_Fix_Cl.hoc
                            
// Start

load_file("nrngui.hoc")
load_file("Cell1_Cl_HCO3_Pas_fine.hoc")
load_file("GDP_Cl_All_short.ses")
load_file("Single_GDP_gGABA-0.789-nGABA-534_Fix_gAMPA_Fix_Cl.hoc")