Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)

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Accession:266823
"... we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. These computational experiments demonstrated that glutamatergic co-stimulation enhances GABA receptor-mediated Cl- influx at low and attenuates or reverses the Cl- efflux at high initial [Cl-]i. The size of glutamatergic influence on GABAergic Cl--fluxes depends on the conductance, decay kinetics, and localization of glutamatergic inputs. Surprisingly, the glutamatergic shift in GABAergic Cl--fluxes is invariant to latencies between GABAergic and glutamatergic inputs over a substantial interval..."
Reference:
1 . Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2021) Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons PLOS Comp Bio
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Short-term Synaptic Plasticity; Synaptic Plasticity; Chloride regulation;
Implementer(s): Jedlicka, Peter [jedlicka at em.uni-frankfurt.de]; Kilb, Werner [wkilb at uni-mainz.de];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
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_For Zip -Neuron-Models_AMPA-GABA
Fig3f-h_Ball-stick_AP_Effect
borgka.mod *
borgkm.mod *
cadiv.mod *
cagk.mod *
cal2.mod *
can2.mod *
cat.mod *
cldif_CA3_NKCC1_HCO3.mod *
gabaA_Cl_HCO3.mod *
kahp.mod *
kdr.mod *
nahh.mod *
vecevent.mod *
cell_soma_dendrite.hoc
cell_soma_dendrite_AP.hoc
cell_soma_dendrite_bpAP.hoc
cell_soma_dendrite_HH.hoc
cell_soma_dendrite_VGCa.hoc
GABA-AMPA_BS_defined_Conditions_for Plots.hoc
GABA-AMPA_BS_Dif-gAMPA_Var-Cl.hoc
init_Cldif.hoc *
Isolated_Dendrite.ses *
start_GABA-AMPA_BS_Dif-gAMPA_Var-Cl.hoc *
start_GABA-AMPA_BS-AP_Dif-gAMPA_Var-Cl.hoc
start_GABA-AMPA_BS-bpAP_Dif-gAMPA_Var-Cl.hoc
start_GABA-AMPA_BS-HH_Dif-gAMPA_Var-Cl.hoc
start_GABA-AMPA_BS-VGCa_Dif-gAMPA_Var-Cl.hoc
start_GABA-AMPA_BS-wo_Dif-gAMPA_Var-Cl.hoc *
start_single_GABA-AMPA.hoc
start_single_GABA-AMPA_AP.hoc
start_single_GABA-AMPA_HH.hoc
test_a.hoc *
                            
TITLE Borg-Graham K-M channel

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
        (mM) = (milli/liter)

}

PARAMETER {
        cai (mM)
	v (mV)
        ek (mV)
	celsius 	(degC)
	gkmbar=.003 (mho/cm2)
        vhalf=-55   (mV)
        a0=0.006      (/ms)
        zeta=-10    (1)
        gm=0.06   (1)
        st=1
}


NEURON {
	SUFFIX borgkm
	USEION k READ ek WRITE ik
        RANGE gkmbar
        GLOBAL inf,tau
}

STATE {
        m
}

ASSIGNED {
	ik (mA/cm2)
        inf
        tau
}

INITIAL {
        rate(v)
        m=inf
}

BREAKPOINT {
	SOLVE state METHOD cnexp
	ik = gkmbar*m^st*(v-ek)

}

FUNCTION alp(v(mV)) {
  alp = exp( 1.e-3*zeta*(v-vhalf)*9.648e4/(8.315*(273.16+celsius)))
}

FUNCTION bet(v(mV)) {
  bet = exp(1.e-3*zeta*gm*(v-vhalf)*9.648e4/(8.315*(273.16+celsius))) 
}

DERIVATIVE state {
        rate(v)
        m' = (inf - m)/tau
}

PROCEDURE rate(v (mV)) { :callable from hoc
        LOCAL a,q10
        q10=5^((celsius-23)/10)
        a = alp(v)
        inf = 1/(1 + a)
        tau = bet(v)/(q10*a0*(1+a))
}