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Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. 2021)
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Model Information
Model File
Accession:
266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 .
Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons.
J Neurophysiology
125
:1501-1516
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s):
I h;
TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Python;
NetPyNE;
Model Concept(s):
Impedance;
Implementer(s):
Kelley, Craig;
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex M1 L5B pyramidal pyramidal tract GLU cell
;
I h
;
TASK channel
;
/
L5PYR_Resonance-master
models
AckerAntic
mod
ampa.mod
*
Other models using ampa.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
ca.mod
*
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A model of optimal learning with redundant synaptic connections (Hiratani & Fukai 2018)
Altered complexity in layer 2/3 pyramidal neurons (Luuk van der Velden et al. 2012)
Biophysically realistic neural modeling of the MEG mu rhythm (Jones et al. 2009)
Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)
Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Engaging distinct oscillatory neocortical circuits (Vierling-Claassen et al. 2010)
Excitability of PFC Basal Dendrites (Acker and Antic 2009)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)
Stochastic Ih and Na-channels in pyramidal neuron dendrites (Kole et al 2006)
Ca_HVA.mod
*
Other models using Ca_HVA.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Effect of ionic diffusion on extracellular potentials (Halnes et al 2016)
Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
Human Cortical L5 Pyramidal Cell (Rich et al. 2021)
Impedance spectrum in cortical tissue: implications for LFP signal propagation (Miceli et al. 2017)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015)
Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013)
Sensory-evoked responses of L5 pyramidal tract neurons (Egger et al 2020)
Cad.mod
*
Other models using Cad.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
cadyn.mod
*
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Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
CaDynamics_E2.mod
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Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Effect of ionic diffusion on extracellular potentials (Halnes et al 2016)
Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
Human Cortical L5 Pyramidal Cell (Rich et al. 2021)
Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al accepted)
Impedance spectrum in cortical tissue: implications for LFP signal propagation (Miceli et al. 2017)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Mice Somatosensory L2/3 Pyramidal cells (Iascone et al 2020)
Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015)
Mirror Neuron (Antunes et al 2017)
Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013)
Sensory-evoked responses of L5 pyramidal tract neurons (Egger et al 2020)
Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
canin.mod
*
Other models using canin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
CaT.mod
*
Other models using CaT.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
gabaa.mod
*
Other models using gabaa.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
gabab.mod
*
Other models using gabab.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
Gfluctp.mod
*
Other models using Gfluctp.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
glutamate.mod
*
Other models using glutamate.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
h_kole.mod
*
Other models using h_kole.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
h_migliore.mod
*
Other models using h_migliore.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
hin.mod
*
Other models using hin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
Ih.mod
*
Other models using Ih.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
IKsin.mod
*
Other models using IKsin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
IL.mod
*
Other models using IL.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
kadist.mod
*
Other models using kadist.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
kapin.mod
*
Other models using kapin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
kaprox.mod
*
Other models using kaprox.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
kBK.mod
*
Other models using kBK.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
kctin.mod
*
Other models using kctin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kdrin.mod
*
Other models using kdrin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kv.mod
*
Other models using kv.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Excitability of PFC Basal Dendrites (Acker and Antic 2009)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
MyExp2SynBB.mod
*
Other models using MyExp2SynBB.mod:
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
na.mod
*
Other models using na.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
nafx.mod
*
Other models using nafx.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
NMDA.mod
*
Other models using NMDA.mod:
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
NMDAeee.mod
*
Other models using NMDAeee.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
NMDAmajor.mod
PlateauConductance.mod
*
Other models using PlateauConductance.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
SK_E2.mod
*
Other models using SK_E2.mod:
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Effect of ionic diffusion on extracellular potentials (Halnes et al 2016)
Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
Human Cortical L5 Pyramidal Cell (Rich et al. 2021)
Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al accepted)
Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al accepted)
Impedance spectrum in cortical tissue: implications for LFP signal propagation (Miceli et al. 2017)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Mice Somatosensory L2/3 Pyramidal cells (Iascone et al 2020)
Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015)
Mirror Neuron (Antunes et al 2017)
Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013)
Sensory-evoked responses of L5 pyramidal tract neurons (Egger et al 2020)
Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
vecstim.mod
*
Other models using vecstim.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
vmax.mod
*
Other models using vmax.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Excitability of PFC Basal Dendrites (Acker and Antic 2009)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
ghk.inc
*
Other models using ghk.inc:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
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