Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

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Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
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L5PYR_Resonance-master
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Neymotin
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cal_mig.mod *
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gabab.mod *
h_BS.mod *
h_harnett.mod
h_kole.mod *
h_migliore.mod *
HCN1.mod *
hin.mod *
IC.mod *
ican_sidi.mod *
IKsin.mod *
kadist.mod *
kap_BS.mod *
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kBK.mod *
kctin.mod *
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kdrin.mod *
MyExp2SynBB.mod *
MyExp2SynNMDABB.mod *
nafx.mod *
nap_sidi.mod *
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savedist.mod *
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ghk.inc *
misc.h
parameters.multi *
                            
TITLE  H-current that uses Na ions
: Updated to use Cvode by Yiota Poirazi 12/1/2005

NEURON {
	SUFFIX hin
        RANGE  gbar,vhalf, K, taun, ninf, g, ihi    
	USEION hi READ ehi WRITE ihi VALENCE 1      

}

UNITS {
	(um) = (micrometer)
	(mA) = (milliamp)
	(uA) = (microamp)
	(mV) = (millivolt)
	(pmho) = (picomho)
	(mmho) = (millimho)
}

:INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}

PARAMETER {              
        ena    = 55    (mV)
        ehi     = -10   (mV)
	K      = 10.0   (mV)
	gbar   = 0     (mho/cm2)  : initialize conductance to zero
	vhalf  = -90   (mV)       : half potential
}	


STATE {                
	n
}

ASSIGNED {            
        v 
:	ina (mA/cm2)
	ihi (mA/cm2)
	ninf
	taun (ms)
	g
}


INITIAL {               
	rates()	
	n = ninf
	g = gbar*n
	ihi = g*(v-ehi)
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	g = gbar*n  
	ihi = g*(v-ehi)  
}

DERIVATIVE states {
	rates()
        n' = (ninf - n)/taun
}

PROCEDURE rates() {  
 
 	if (v > -10) {
	   taun = 1
	} else {
           taun = 2*(1/(exp((v+145)/-17.5)+exp((v+16.8)/16.5)) + 10) :h activation tau +5

	}  
         ninf = 1 - (1 / (1 + exp((vhalf - v)/K)))                  :steady state value
}