Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

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Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
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L5PYR_Resonance-master
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DuraBernal
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misc.h
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TITLE Anomalous rectifier current for RD Traub, J Neurophysiol 89:909-921, 2003

COMMENT

	Implemented by Maciej Lazarewicz 2003 (mlazarew@seas.upenn.edu)

ENDCOMMENT

INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) }

UNITS { 
	(mV) = (millivolt) 
	(mA) = (milliamp) 
} 
NEURON { 
	SUFFIX ar
	NONSPECIFIC_CURRENT i
	RANGE gbar, i
}
PARAMETER { 
	gbar = 0.0 	(mho/cm2)
	v		(mV) 
	erev = -35	(mV)  
} 
ASSIGNED { 
	i 		(mA/cm2) 
	minf 		(1)
	mtau 		(ms) 
} 
STATE {
	m
}
BREAKPOINT { 
	SOLVE states METHOD cnexp
	i = gbar * m * ( v - erev ) 
} 
INITIAL { 
	minf  = 1 / ( 1 + exp( ( v + 75 ) / 5.5 ) )
	mtau = 1 / ( exp( -14.6 - 0.086 * v ) + exp( -1.87 + 0.07 * v ) )
	m = minf
	: m = 0.25 : ??
} 
DERIVATIVE states { 
	minf  = 1 / ( 1 + exp( ( v + 75 ) / 5.5 ) )
	mtau = 1 / ( exp( -14.6 - 0.086 * v ) + exp( -1.87 + 0.07 * v ) )
	m' = ( minf - m ) / mtau 
}