Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al 2021)

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Accession:267067
Based on the Layer 5 thick-tufted pyramidal cell from the Blue Brain Project, we modify the distribution of the sodium channel Nav1.2 to recapitulate an increase in excitability observed in ex vivo slice experiments.
Reference:
1 . Spratt PWE, Alexander RPD, Ben-Shalom R, Sahagun A, Kyoung H, Keeshen CM, Sanders SJ, Bender KJ (2021) Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells Cell Rep. 36(5):109483 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s): Neocortex layer 5 pyramidal cell;
Channel(s): I h; I M; I Potassium; I Sodium; I L high threshold; I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.2 SCN2A;
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s):
Implementer(s): Ben-Shalom, Roy [rbenshalom at ucdavis.edu]; Kyoung, Henry [hkyoung at berkeley.edu];
Search NeuronDB for information about:  I L high threshold; I T low threshold; I M; I h; I Sodium; I Potassium;
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SprattEtAl2021
Na12 Analysis
mechanisms
morphology
params
Stims
Volts
README *
axon_utils.hoc
biophysics.hoc *
cellinfo.json *
constants.hoc *
creategui.hoc *
createsimulation.hoc *
fit.hoc *
gui.ses *
init.hoc *
LICENSE *
morphology.hoc *
mosinit.hoc *
NaV12_analysis.ipynb *
ringplot.hoc *
run.py *
run_RmpRiTau.py *
runModel.hoc *
template.hoc *
topo_code.hoc *
                            
/*                                                                               
Copyright (c) 2015 EPFL-BBP, All rights reserved.                                
                                                                                 
THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS''                    
AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO,            
THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR           
PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJECT                 
BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR           
CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF             
SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR                  
BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY,            
WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE             
OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN           
IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.                                    
                                                                                 
This work is licensed under a 
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
To view a copy of this license, visit 
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode or send a letter to 
Creative Commons, 
171 Second Street, Suite 300, 
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*/           

/*                                                                               
 * @file init.hoc                                                           
 * @brief Initialisation                                
 * @author Werner Van Geit @ BBP                                                 
 * @date 2015                                                                    
*/        

//----------------------------------------------------------------------------
//  define a panel to run the different demos
//----------------------------------------------------------------------------

load_file("nrngui.hoc")
load_file("constants.hoc")
//load_file("creategui.hoc")
load_file("createsimulation.hoc")

// By default, disable the step currents
strdef stepcurrent
stepcurrent = "none"

// By default, enable synapses
synapses_enabled = 0

// Set up simulation
create_cell(synapses_enabled)
//create_recording()


// Start the GUI
//make_mainwindow(cell)

// Save the windows that already exist before this initialisation
//pwmcnt = PWManager[0].count

/** Procedure linked to the Init & Run button */ 
proc restart() {
    cleanup()	

    // make_plottingpanel()
    create_stimulus(stepcurrent)

    //simulate()

    //save_recording()
}
load_file("axon_utils.hoc")
/** Cleanup previous windows / simulations */