Olfactory Bulb Network (Davison et al 2003)

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A biologically-detailed model of the mammalian olfactory bulb, incorporating the mitral and granule cells and the dendrodendritic synapses between them. The results of simulation experiments with electrical stimulation agree closely in most details with published experimental data. The model predicts that the time course of dendrodendritic inhibition is dependent on the network connectivity as well as on the intrinsic parameters of the synapses. In response to simulated odor stimulation, strongly activated mitral cells tend to suppress neighboring cells, the mitral cells readily synchronize their firing, and increasing the stimulus intensity increases the degree of synchronization. For more details, see the reference below.
1 . Davison AP, Feng J, Brown D (2003) Dendrodendritic inhibition and simulated odor responses in a detailed olfactory bulb network model. J Neurophysiol 90:1921-35 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I L high threshold; I A; I K; I K,leak; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Synchronization; Spatio-temporal Activity Patterns; Olfaction;
Implementer(s): Davison, Andrew [Andrew.Davison at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I A; I K; I K,leak; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Gaba; Glutamate;
cadecay.mod *
flushf.mod *
kA.mod *
kca.mod *
kfasttab.mod *
kM.mod *
kslowtab.mod *
lcafixed.mod *
nafast.mod *
nagran.mod *
nmdanet.mod *
calcisilag.hoc *
ddi_baseline.gnu *
ddi_baseline.ses *
experiment_ddi_baseline.hoc *
experiment_odour_baseline.hoc *
granule.tem *
init.hoc *
input.hoc *
input1 *
mathslib.hoc *
mitral.tem *
mosinit.hoc *
odour_baseline.gnu *
odour_baseline.ses *
parameters_ddi_baseline.hoc *
parameters_odour_baseline.hoc *
screenshot.png *
tabchannels.dat *
tabchannels.hoc *
# gnuplot file to produce a figure similar to Figure 2
# in Davison A.P., Feng J. and Brown D. (2003) J. Neurophysiol.

# Note that the figure produced will not match exactly the
# published figure due to differences in the sequence of
# random numbers used to set up the network.

# gnuplot is available from http://www.gnuplot.info

set term postscript portrait enhanced mono solid "Helvetica" 8
set output "ddi_baseline.eps"

set size 0.49,0.5
set multiplot
set size 0.48,0.1
set nokey
set noxtics
set noborder
set noytics
set tmargin 0
set rmargin 0

#  mitral cell
set label 1 '{/Helvetica=14 A}' at screen 0,0.49
set arrow 1 from 1200,-30 to 1000,-30 nohead linewidth 2
set arrow 2 from 1200,-30 to 1200,20 nohead linewidth 2
set label 2 "200 ms" at 1000,-45
set label 3 " 50 mV" at 1200,-10 left
set origin 0.01,0.4
plot [0:1500][-75:50] "ddi_baseline.curvs" using 1:3 with lines linewidth 0.5

# granule cell
set noarrow
set nolabel 2
set nolabel 3
set label 1 '{/Helvetica=14 B}' at screen 0,0.39
set origin 0.01,0.3
plot [0:1500][-75:50] "ddi_baseline.curvs" using 1:4 with lines linewidth 0.5

set label 1 '{/Helvetica=14 C}' at screen 0,0.29
set arrow 1 from 1200,-1.8 to 1200,-0.8 nohead linewidth 2
set label 2 " 1 nA" at 1200,-1.3 left
set origin 0.01,0.2
plot [0:1500][-3.5:0] "ddi_baseline.curvs" using 1:2 with lines linewidth 0.5

# Raster
set noarrow
set nolabel 2
set noborder
set label 1 '{/Helvetica=14 D}' at screen 0,0.19
set origin 0.01,0.1
plot [0:1500][-1250:1250] "ddi_baseline.gran.ras" using 4:3 with dots, "ddi_baseline.gran.ras" using 4:($3-2500) with dots linetype 1

# Histogram
set border 1 linewidth 0.5
set label 1 '{/Helvetica=14 E}' at screen 0,0.09
set origin 0.01,0.0
set arrow 1 from 1200,80 to 1200,180 nohead linewidth 2
set label 2 "100 spikes per second" at 1180,120 right
plot [0:1500][0:300] "ddi_baseline.gran.hist" using 0:1 with steps linewidth 0.5