/*--------------------------------------------------------------
TEMPLATE FILE FOR DEFINING RETICULAR NEURONS
--------------------------------------------
One compartment model and currents derived from:
Destexhe, A., Contreras, D., Sejnowski, T.J. and Steriade, M.
A model of spindle rhythmicity in the isolated thalamic reticular
nucleus. J. Neurophysiol. 72: 803-818, 1994.
Destexhe, A., Contreras, D., Steriade, M., Sejnowski, T.J.,
and Huguenard, J.R. In vivo, in vitro and computational analysis of
dendritic calcium currents in thalamic reticular neurons.
Journal of Neuroscience 16: 169-185, 1996.
Modifications:
- passive parameters estimated from simplex
- IT2: Q10=2.5, strong conductance for broad bursts
- no IK[Ca], no ICAN
- Ca++: simple decay only
This model is described in detail in:
Destexhe, A., Bal, T., McCormick, D.A. and Sejnowski, T.J.
Ionic mechanisms underlying synchronized oscillations and propagating
waves in a model of ferret thalamic slices. Journal of Neurophysiology
76: 2049-2070, 1996.
See also http://www.cnl.salk.edu/~alain , http://cns.fmed.ulaval.ca
Alain Destexhe, Salk Institute and Laval University, 1995
--------------------------------------------------------------*/
print " "
print " << defining template for one-compartment sRE cell >> "
print " "
begintemplate sRE // create a new template object
public soma
create soma[1] // one-compartment of 14260 um2
soma {
nseg = 1
diam = 70
L = 64.86
cm=1
}
proc init() { local v_potassium, v_sodium
v_potassium = -100 // potassium reversal potential
v_sodium = 50 // sodium reversal potential
soma {
Ra = 100 // geometry
nseg = 1
diam = 70
L = 64.86
insert pas // leak current
e_pas = -90
g_pas = 5e-5
insert hh2 // Hodgin-Huxley INa and IK
ek = v_potassium
ena = v_sodium
vtraub_hh2 = -55
gnabar_hh2 = 0.2
gkbar_hh2 = 0.02
insert it2 // reticular IT current
cai = 2.4e-4
cao = 2
eca = 120
shift_it2 = 2
qm_it2 = 2.5 // low q10
qh_it2 = 2.5
gcabar_it2 = 0.003 // strong
insert cad // calcium decay
depth_cad = 1
taur_cad = 5
cainf_cad = 2.4e-4
kt_cad = 0 // no pump
}
print " "
print "<< sRE: passive, INa, IK, ITs, IAHP and Ca++ decay inserted >>"
print " "
}
endtemplate sRE
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