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Dentate gyrus network model (Santhakumar et al 2005)
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Accession:
51781
Mossy cell loss and mossy fiber sprouting are two characteristic consequences of repeated seizures and head trauma. However, their precise contributions to the hyperexcitable state are not well understood. Because it is difficult, and frequently impossible, to independently examine using experimental techniques whether it is the loss of mossy cells or the sprouting of mossy fibers that leads to dentate hyperexcitability, we built a biophysically realistic and anatomically representative computational model of the dentate gyrus to examine this question. The 527-cell model, containing granule, mossy, basket, and hilar cells with axonal projections to the perforant-path termination zone, showed that even weak mossy fiber sprouting (10-15% of the strong sprouting observed in the pilocarpine model of epilepsy) resulted in the spread of seizure-like activity to the adjacent model hippocampal laminae after focal stimulation of the perforant path. See reference for more and details.
Reference:
1 .
Santhakumar V, Aradi I, Soltesz I (2005) Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography.
J Neurophysiol
93
:437-53
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Dentate gyrus;
Cell Type(s):
Dentate gyrus granule GLU cell;
Dentate gyrus mossy cell;
Dentate gyrus basket cell;
Dentate gyrus hilar cell;
Channel(s):
I L high threshold;
I T low threshold;
I K;
I h;
I K,Ca;
I Calcium;
I Potassium;
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
neuroConstruct (web link to model);
Model Concept(s):
Activity Patterns;
Spatio-temporal Activity Patterns;
Axonal Action Potentials;
Epilepsy;
Synaptic Integration;
Implementer(s):
Santhakumar, Vijayalakshmi [santhavi at umdnj.edu];
Search NeuronDB
for information about:
Dentate gyrus granule GLU cell
;
GabaA
;
AMPA
;
I L high threshold
;
I T low threshold
;
I K
;
I h
;
I K,Ca
;
I Calcium
;
I Potassium
;
Files displayed below are from the
NEURON
neuroConstruct
implementation
/
dentategyrusnet2005
readme.html
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Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
CaBK.mod
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Dentate gyrus network model (Tejada et al 2014)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
ccanl.mod
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Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Gfluct2.mod
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Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus network model (Tejada et al 2014)
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Fluctuating synaptic conductances recreate in-vivo-like activity (Destexhe et al 2001)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
gskch.mod
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Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Tejada et al 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
ichan2.mod
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Dentate Gyrus Feed-forward inhibition (Ferrante et al. 2009)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Tejada et al 2014)
Parallel network simulations with NEURON (Migliore et al 2006)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
LcaMig.mod
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CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
nca.mod
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Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
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CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
tca.mod
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Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Tejada et al 2014)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
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dgnetactivity.jpg
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