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T channel currents (Vitko et al 2005)
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Accession:
53965
Computer simulations predict that seven of the SNPs would increase firing of neurons, with three of them inducing oscillations at similar frequencises. 3 representative models from the paper have been submited: a wild-type (WT) recombinant Cav3.2 T-channel, and two of the mutants described in the Vitko et al., 2005 paper (C456S and R788C). See the paper for more and details.
Reference:
1 .
Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E (2005) Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel.
J Neurosci
25
:4844-55
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Ion Channel Kinetics;
Epilepsy;
Implementer(s):
Search NeuronDB
for information about:
I T low threshold
;
Download the displayed file
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zippedModels
Cav32_WT
cells
README
*
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T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
capump.mod
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T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
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Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
IT2.mod
VClamp.mod
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CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
El.oc
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Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Hh8.ses
hH80_2.jpg
Hh8ips2.jpg
Hh8triple.jpg
leak.oc
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T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
loc3.oc
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T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
loc80.oc
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Other models using loc80.oc:
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
locD.oc
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Other models using locD.oc:
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
mosinit.hoc
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Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)
T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
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re1_cc.oc
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T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
re3_cc.oc
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T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
re3_vc.oc
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T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
re80_cc.oc
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re80_vc.oc
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T channel currents (Vitko et al 2005)
reD_cc.oc
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T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
reD_vc.oc
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T channel currents (Vitko et al 2005)
T channel currents (Vitko et al 2005)
rundemo.hoc
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T channel currents (Vitko et al 2005)
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Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
WtEP2.jpg
load_file("nrngui.hoc") xopen("rundemo.hoc")
