Citation Relationships

Legends: Link to a Model Reference cited by multiple papers


Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci 11:178-86 [PubMed]

  • Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)

References and models cited by this paper

References and models that cite this paper

Akemann W, Knöpfel T (2006) Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons. J Neurosci 26:4602-12 [Journal] [PubMed]
  • Cerebellar purkinje cell: interacting Kv3 and Na currents influence firing (Akemann, Knopfel 2006) [Model]
Baranauskas G, Martina M (2006) Sodium currents activate without a Hodgkin-and-Huxley-type delay in central mammalian neurons. J Neurosci 26:671-84 [Journal] [PubMed]
  • Sodium currents activate without a delay (Baranauskas and Martina 2006) [Model]
Boiko T, Rasband MN, Levinson SR, Caldwell JH, Mandel G, Trimmer JS, Matthews G (2001) Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron 30:91-104 [PubMed]
Boiko T, Van Wart A, Caldwell JH, Levinson SR, Trimmer JS, Matthews G (2003) Functional specialization of the axon initial segment by isoform-specific sodium channel targeting. J Neurosci 23:2306-13 [PubMed]
Canavier CC (1999) Sodium dynamics underlying burst firing and putative mechanisms for the regulation of the firing pattern in midbrain dopamine neurons: a computational approach. J Comput Neurosci 6:49-69 [PubMed]
  • Midbrain dopamine neuron: firing patterns (Canavier 1999) [Model]
Clark BA, Monsivais P, Branco T, London M, Häusser M (2005) The site of action potential initiation in cerebellar Purkinje neurons. Nat Neurosci 8:137-9 [Journal] [PubMed]
Colbert CM, Johnston D (1996) Axonal action-potential initiation and Na+ channel densities in the soma and axon initial segment of subicular pyramidal neurons. J Neurosci 16:6676-86 [PubMed]
Colbert CM, Pan E (2002) Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nat Neurosci 5:533-8 [Journal] [PubMed]
COOMBS JS, CURTIS DR, ECCLES JC (1957) The generation of impulses in motoneurones. J Physiol 139:232-49 [PubMed]
Dodge FA, Cooley JW (1973) Action Potential of the Motorneuron. IBM J Res Dev 17:219-29 [Journal]
  • Spinal Motor Neuron (Dodge, Cooley 1973) [Model]
Eccles JC (1964) Presynaptic inhibition The Physiology of synapses :220-238
FATT P (1957) Sequence of events in synaptic activation of a motoneurone. J Neurophysiol 20:61-80 [Journal] [PubMed]
FUORTES MG, FRANK K, BECKER MC (1957) Steps in the production of motoneuron spikes. J Gen Physiol 40:735-52 [PubMed]
Garrido JJ, Giraud P, Carlier E, Fernandes F, Moussif A, Fache MP, Debanne D, Dargent B (2003) A targeting motif involved in sodium channel clustering at the axonal initial segment. Science 300:2091-4 [Journal] [PubMed]
Howard A, Tamas G, Soltesz I (2005) Lighting the chandelier: new vistas for axo-axonic cells. Trends Neurosci 28:310-6 [Journal] [PubMed]
Inda MC, DeFelipe J, Muñoz A (2006) Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells. Proc Natl Acad Sci U S A 103:2920-5 [Journal] [PubMed]
Kaplan MR, Cho MH, Ullian EM, Isom LL, Levinson SR, Barres BA (2001) Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron 30:105-19 [PubMed]
Kole MH, Hallermann S, Stuart GJ (2006) Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output. J Neurosci 26:1677-87 [Journal] [PubMed]
  • Stochastic Ih and Na-channels in pyramidal neuron dendrites (Kole et al 2006) [Model]
Kole MH, Letzkus JJ, Stuart GJ (2007) Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. Neuron 55:633-47 [Journal] [PubMed]
Komada M, Soriano P (2002) [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J Cell Biol 156:337-48 [Journal] [PubMed]
Komai S, Licznerski P, Cetin A, Waters J, Denk W, Brecht M, Osten P (2006) Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development. Nat Neurosci 9:1125-33 [Journal] [PubMed]
Kordeli E, Lambert S, Bennett V (1995) AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J Biol Chem 270:2352-9 [PubMed]
Kuba H, Ishii TM, Ohmori H (2006) Axonal site of spike initiation enhances auditory coincidence detection. Nature 444:1069-72 [Journal] [PubMed]
Lai HC, Jan LY (2006) The distribution and targeting of neuronal voltage-gated ion channels. Nat Rev Neurosci 7:548-62 [Journal] [PubMed]
Lasser-Ross N, Ross WN (1992) Imaging voltage and synaptically activated sodium transients in cerebellar Purkinje cells. Proc Biol Sci 247:35-9 [Journal] [PubMed]
Magee JC, Johnston D (1995) Characterization of single voltage-gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons. J Physiol 487:67-90 [PubMed]
Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron 15:1427-39 [PubMed]
  • Spike Initiation in Neocortical Pyramidal Neurons (Mainen et al 1995) [Model]
Meeks JP, Mennerick S (2007) Action potential initiation and propagation in CA3 pyramidal axons. J Neurophysiol 97:3460-72 [Journal] [PubMed]
Milton RL, Caldwell JH (1990) Na current in membrane blebs: implications for channel mobility and patch clamp recording. J Neurosci 10:885-93 [PubMed]
Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11 [PubMed]
  • Site of impulse initiation in a neuron (Moore et al 1983) [Model]
Nakada C, Ritchie K, Oba Y, Nakamura M, Hotta Y, Iino R, Kasai RS, Yamaguchi K, Fujiwara T, Kusumi A (2003) Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization. Nat Cell Biol 5:626-32 [Journal] [PubMed]
Neumcke B, Stämpfli R (1982) Sodium currents and sodium-current fluctuations in rat myelinated nerve fibres. J Physiol 329:163-84 [PubMed]
Palmer LM, Stuart GJ (2006) Site of action potential initiation in layer 5 pyramidal neurons. J Neurosci 26:1854-63 [Journal] [PubMed]
Peters A, Proskauer CC, Kaiserman-Abramof IR (1968) The small pyramidal neuron of the rat cerebral cortex. The axon hillock and initial segment. J Cell Biol 39:604-19 [PubMed]
Rapp M, Yarom Y, Segev I (1996) Modeling back propagating action potential in weakly excitable dendrites of neocortical pyramidal cells. Proc Natl Acad Sci U S A 93:11985-90 [PubMed]
Rush AM, Dib-Hajj SD, Waxman SG (2005) Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones. J Physiol 564:803-15 [Journal] [PubMed]
Shrager P (1989) Sodium channels in single demyelinated mammalian axons. Brain Res 483:149-54 [PubMed]
Shu Y, Duque A, Yu Y, Haider B, McCormick DA (2007) Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. J Neurophysiol 97:746-60 [Journal] [PubMed]
  • Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007) [Model]
Sloper JJ, Powell TP (1979) A study of the axon initial segment and proximal axon of neurons in the primate motor and somatic sensory cortices. Philos Trans R Soc Lond B Biol Sci 285:173-97 [Journal] [PubMed]
Stuart G, Häusser M (1994) Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron 13:703-12 [PubMed]
Stuart G, Schiller J, Sakmann B (1997) Action potential initiation and propagation in rat neocortical pyramidal neurons. J Physiol 505 ( Pt 3):617-32 [PubMed]
Stuart GJ, Dodt HU, Sakmann B (1993) Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflugers Arch 423:511-8 [PubMed]
Stuart GJ, Sakmann B (1994) Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367:69-72 [Journal] [PubMed]
Taddese A, Bean BP (2002) Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron 33:587-600 [PubMed]
Ulbricht W (2005) Sodium channel inactivation: molecular determinants and modulation. Physiol Rev 85:1271-301 [Journal] [PubMed]
Van Wart A, Trimmer JS, Matthews G (2007) Polarized distribution of ion channels within microdomains of the axon initial segment. J Comp Neurol 500:339-52 [Journal] [PubMed]
Winckler B, Forscher P, Mellman I (1999) A diffusion barrier maintains distribution of membrane proteins in polarized neurons. Nature 397:698-701 [Journal] [PubMed]
Wollner DA, Catterall WA (1986) Localization of sodium channels in axon hillocks and initial segments of retinal ganglion cells. Proc Natl Acad Sci U S A 83:8424-8 [PubMed]
Zhou D, Lambert S, Malen PL, Carpenter S, Boland LM, Bennett V (1998) AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J Cell Biol 143:1295-304 [PubMed]
Aberra AS, Peterchev AV, Grill WM (2018) Biophysically realistic neuron models for simulation of cortical stimulation. J Neural Eng 15:066023 [Journal] [PubMed]
  • Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018) [Model]
Acker CD, Antic SD (2009) Quantitative assessment of the distributions of membrane conductances involved in action potential backpropagation along basal dendrites. J Neurophysiol 101:1524-41 [Journal] [PubMed]
  • Excitability of PFC Basal Dendrites (Acker and Antic 2009) [Model]
Bahl A, Stemmler MB, Herz AV, Roth A (2012) Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data. J Neurosci Methods 210:22-34 [Journal] [PubMed]
  • A set of reduced models of layer 5 pyramidal neurons (Bahl et al. 2012) [Model]
Balbi P, Martinoia S, Massobrio P (2015) Axon-somatic back-propagation in detailed models of spinal alpha motoneurons. Front Comput Neurosci 9:15 [Journal] [PubMed]
  • Axon-somatic back-propagation in a detailed model of cat spinal motoneuron (Balbi et al, 2015) [Model]
Ben-Shalom R, Keeshen CM, Berrios KN, An JY, Sanders SJ, Bender KJ (2017) Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures. Biol Psychiatry 82:224-232 [Journal] [PubMed]
  • Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017) [Model]
Brette R (2013) Sharpness of spike initiation in neurons explained by compartmentalization. PLoS Comput Biol 9:e1003338 [Journal] [PubMed]
  • Sharpness of spike initiation in neurons explained by compartmentalization (Brette 2013) [Model]
Casale AE, McCormick DA (2011) Active action potential propagation but not initiation in thalamic interneuron dendrites. J Neurosci 31:18289-302 [Journal] [PubMed]
  • Active dendritic action potential propagation (Casale & McCormick 2011) [Model]
Connelly WM, Crunelli V, Errington AC (2015) The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons. J Neurosci 35:15505-22 [Journal] [PubMed]
  • Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016) [Model]
Dudman JT, Nolan MF (2009) Stochastically gating ion channels enable patterned spike firing through activity-dependent modulation of spike probability. PLoS Comput Biol 5:e1000290 [Journal] [PubMed]
Edgerton JR, Hanson JE, Günay C, Jaeger D (2010) Dendritic sodium channels regulate network integration in globus pallidus neurons: a modeling study. J Neurosci 30:15146-59 [Journal] [PubMed]
  • Globus pallidus neuron models with differing dendritic Na channel expression (Edgerton et al., 2010) [Model]
Fleidervish IA, Libman L, Katz E, Gutnick MJ (2008) Endogenous polyamines regulate cortical neuronal excitability by blocking voltage-gated Na+ channels. Proc Natl Acad Sci U S A 105:18994-9 [Journal] [PubMed]
Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA (2011) Somatic membrane potential and Kv1 channels control spike repolarization in cortical axon collaterals and presynaptic boutons. J Neurosci 31:15490-8 [Journal] [PubMed]
  • Spike repolarization in axon collaterals (Foust et al. 2011) [Model]
Frey U, Egert U, Heer F, Hafizovic S, Hierlemann A (2009) Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices. Biosens Bioelectron 24:2191-8 [Journal] [PubMed]
Gleeson P, Crook S, Cannon RC, Hines ML, Billings GO, Farinella M, Morse TM, Davison AP, Ray S, Bhalla US, Barnes SR, Dimitrova YD, Silver RA (2010) NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. PLoS Comput Biol 6:e1000815 [Journal] [PubMed]
Grossman N, Simiaki V, Martinet C, Toumazou C, Schultz SR, Nikolic K (2013) The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials. J Comput Neurosci 34:477-88 [Journal] [PubMed]
Gulledge AT, Carnevale NT, Stuart GJ (2012) Electrical advantages of dendritic spines. PLoS One 7:e36007 [Journal] [PubMed]
Günay C, Sieling FH, Dharmar L, Lin WH, Wolfram V, Marley R, Baines RA, Prinz AA (2015) Distal spike initiation zone location estimation by morphological simulation of ionic current filtering demonstrated in a novel model of an identified Drosophila motoneuron. PLoS Comput Biol 11:e1004189 [Journal] [PubMed]
  • Drosophila 3rd instar larval aCC motoneuron (Gunay et al. 2015) [Model]
Hallermann S, de Kock CP, Stuart GJ, Kole MH (2012) State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nat Neurosci 15:1007-14 [Journal] [PubMed]
  • State and location dependence of action potential metabolic cost (Hallermann et al., 2012) [Model]
Hay E, Schürmann F, Markram H, Segev I (2013) Preserving axosomatic spiking features despite diverse dendritic morphology. J Neurophysiol 109:2972-81 [Journal] [PubMed]
  • Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013) [Model]
Hendrickson EB, Edgerton JR, Jaeger D (2011) The use of automated parameter searches to improve ion channel kinetics for neural modeling. J Comput Neurosci 31:329-46 [Journal] [PubMed]
Hsu CL, Zhao X, Milstein AD, Spruston N (2018) Persistent sodium current mediates the steep voltage dependence of spatial coding in hippocampal pyramidal neurons Neuron 99:1-16 [Journal]
  • CA1 pyramidal neuron: Persistent Na current mediates steep synaptic amplification (Hsu et al 2018) [Model]
Hu W, Tian C, Li T, Yang M, Hou H, Shu Y (2009) Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nat Neurosci 12:996-1002 [Journal] [PubMed]
  • Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009) [Model]
Ju H, Hines ML, Yu Y (2016) Cable energy function of cortical axons. Sci Rep 6:29686 [Journal] [PubMed]
Lezmy J, Lipinsky M, Khrapunsky Y, Patrich E, Shalom L, Peretz A, Fleidervish IA, Attali B (2017) M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment. Proc Natl Acad Sci U S A 114:E10234-E10243 [Journal] [PubMed]
Liu CY, Xiao C, Fraser SE, Lester HA, Koos DS (2012) Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents. J Neurophysiol 108:1318-34 [Journal] [PubMed]
  • Model of repetitive firing in Grueneberg ganglion olfactory neurons (Liu et al., 2012) [Model]
Meza RC, López-Jury L, Canavier CC, Henny P (2018) Role of the Axon Initial Segment in the Control of Spontaneous Frequency of Nigral Dopaminergic Neurons In Vivo. J Neurosci 38:733-744 [Journal] [PubMed]
  • Role of the AIS in the control of spontaneous frequency of dopaminergic neurons (Meza et al 2017) [Model]
Moubarak E, Engel D, Dufour MA, Tapia M, Tell F, Goaillard JM (2019) Robustness to Axon Initial Segment Variation Is Explained by Somatodendritic Excitability in Rat Substantia Nigra Dopaminergic Neurons. J Neurosci 39:5044-5063 [Journal] [PubMed]
  • Dopaminergic subtantia nigra neuron (Moubarak et al 2019) [Model]
Munro E, Kopell N (2012) Subthreshold somatic voltage in neocortical pyramidal cells can control whether spikes propagate from the axonal plexus to axon terminals: a model study. J Neurophysiol 107:2833-52 [Journal] [PubMed]
  • Neocort. pyramidal cells subthreshold somatic voltage controls spike propagation (Munro Kopell 2012) [Model]
Ona-Jodar T, Gerkau NJ, Sara Aghvami S, Rose CR, Egger V (2017) Two-Photon Na+ Imaging Reports Somatically Evoked Action Potentials in Rat Olfactory Bulb Mitral and Granule Cell Neurites. Front Cell Neurosci 11:50 [Journal] [PubMed]
  • Na+ Signals in olfactory bulb neurons (granule cell model) (Ona-Jodar et al. 2017) [Model]
Öz P, Huang M, Wolf F (2015) Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment. J Comput Neurosci 39:63-75 [Journal] [PubMed]
  • MCCAIS model (multicompartmental cooperative AIS) (Öz et al 2015) [Model]
Parekh R, Ascoli GA (2013) Neuronal morphology goes digital: a research hub for cellular and system neuroscience. Neuron 77:1017-38 [Journal] [PubMed]
  • Neuronal morphology goes digital ... (Parekh & Ascoli 2013) [Model]
Platkiewicz J, Brette R (2010) A threshold equation for action potential initiation. PLoS Comput Biol 6:e1000850 [Journal] [PubMed]
  • A threshold equation for action potential initiation (Platkiewicz & Brette 2010) [Model]
Radecki DZ, Johnson EL, Brown AK, Meshkin NT, Perrine SA, Gow A (2018) Corticohippocampal Dysfunction In The OBiden Mouse Model Of Primary Oligodendrogliopathy. Sci Rep 8:16116 [Journal] [PubMed]
Reetz O, Stadler K, Strauss U (2014) Protein kinase C activation mediates interferon-ß-induced neuronal excitability changes in neocortical pyramidal neurons. J Neuroinflammation 11:185 [Journal] [PubMed]
  • Firing neocortical layer V pyramidal neuron (Reetz et al. 2014; Stadler et al. 2014) [Model]
Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. J Neurophysiol 100:2361-80 [Journal] [PubMed]
  • Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008) [Model]
Schmidt-Hieber C, Bischofberger J (2010) Fast sodium channel gating supports localized and efficient axonal action potential initiation. J Neurosci 30:10233-42 [Journal] [PubMed]
  • Fast sodium channel gating in mossy fiber axons (Schmidt-Hieber et al. 2010) [Model]
Singh C, Levy WB (2017) A consensus layer V pyramidal neuron can sustain interpulse-interval coding. PLoS One 12:e0180839 [Journal] [PubMed]
  • Stochastic layer V pyramidal neuron: interpulse interval coding and noise (Singh & Levy 2017) [Model]
Vascak M, Sun J, Baer M, Jacobs KM, Povlishock JT (2017) Mild Traumatic Brain Injury Evokes Pyramidal Neuron Axon Initial Segment Plasticity and Diffuse Presynaptic Inhibitory Terminal Loss. Front Cell Neurosci 11:157 [Journal] [PubMed]
Wilmes KA, Sprekeler H, Schreiber S (2016) Inhibition as a Binary Switch for Excitatory Plasticity in Pyramidal Neurons. PLoS Comput Biol 12:e1004768 [Journal] [PubMed]
  • Inhibition of bAPs and Ca2+ spikes in a multi-compartment pyramidal neuron model (Wilmes et al 2016) [Model]
Yu Y, Shu Y, McCormick DA (2008) Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. J Neurosci 28:7260-72 [Journal] [PubMed]
  • AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008) [Model]
(96 refs)