Synchronization by D4 dopamine receptor-mediated phospholipid methylation (Kuznetsova, Deth 2008)

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"We describe a new molecular mechanism of dopamine-induced membrane protein modulation that can tune neuronal oscillation frequency to attention related gamma rhythm. This mechanism is based on the unique ability of D4 dopamine receptors (D4R) to carry out phospholipid methylation (PLM) that may affect the kinetics of ion channels. We show that by deceasing the inertia of the delayed rectifier potassium channel, a transition to 40 Hz oscillations can be achieved. ..."
1 . Kuznetsova AY, Deth RC (2008) A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation. J Comput Neurosci 24:314-29 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,t; I T low threshold; I K; I K,Ca;
Gap Junctions:
Transmitter(s): Dopamine;
Simulation Environment: XPP;
Model Concept(s): Activity Patterns; Oscillations; Synchronization; Simplified Models; Signaling pathways;
Implementer(s): Kuznetsova, Anna [anna.kuznetsova at];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; I Na,t; I T low threshold; I K; I K,Ca; Dopamine;
# Kuznetsova and Deth, JCN, 2007
# Model E cell
init V1=-0.70  R1=0.24  CA1=0.15 H1=0.37
par Ie=0.6

par GCA=0.1, GH=4.0
par GK=26.0
par TR1=4.2
par TS=14.0
par TH=45.0



@ METHOD=stiff, TOLERANCE=.00001
@ dt=.01, total=400, xplot=V1,yplot=CA1
@ xmin=-0.8,xmax=0.4,ymin=0.0,ymax=0.4
@ xlo=-0.8,ylo=0.0,xhi=0.4,yhi=0.4,bound=30000,MAXSTOR=400000