Modelling enteric neuron populations and muscle fed-state motor patterns (Chambers et al. 2011)

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"After a meal, the gastrointestinal tract exhibits a set of behaviours known as the fed state. ... Segmentation manifests as rhythmic local constrictions that do not propagate along the intestine. ... We investigated the enteric circuits that regulate segmentation focusing on a central feature of the ENS: a recurrent excitatory network of intrinsic sensory neurons (ISNs) which are characterized by prolonged after-hyperpolarizing potentials (AHPs) following their action potentials. ..."
1 . Chambers JD, Bornstein JC, Thomas EA (2011) Multiple Neural Oscillators and Muscle Feedback Are Required for the Intestinal Fed State Motor Program PLoS ONE 6(5):e119597-.
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Model Type: Realistic Network; Neural mass;
Brain Region(s)/Organism:
Cell Type(s):
Gap Junctions:
Simulation Environment: MATLAB; Simulink;
Model Concept(s): Activity Patterns;
Implementer(s): Chambers, Jordan [jordandchambers at];
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