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Epileptic seizure model with Morris-Lecar neurons (Beverlin and Netoff 2011)
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Here we use phase-response curves (PRC) from Morris-Lecar (M-L) model neurons with synaptic depression and gradually decrease input current to cells within a network simulation. This method effectively decreases firing rates resulting in a shift to greater network synchrony illustrating a possible mechanism of the transition phenomenon. PRCs are measured from the M-L conductance based model cell with a range of input currents within the limit cycle. A large network of 3000 excitatory neurons is simulated with a network topology generated from second-order statistics which allows a range of population synchrony. The population synchrony of the oscillating cells is measured with the Kuramoto order parameter, which reveals a transition from tonic to clonic phase exhibited by our model network.
Beverlin B, Kakalios J, Nykamp D, Netoff TI (2012) Dynamical changes in neurons during seizures determine tonic to clonic shift.
J Comput Neurosci
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Abstract Morris-Lecar neuron;
Beverlin, Bryce ;
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