Models that contain the Modeling Application : Yale HMM (Home Page)

(Hidden Markov Model simulator)
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1.  Kinetic properties of voltage gated Na channel (Nayak and Sikdar 2007)
Here we illustrate novel non-linear properties of voltage gated Na+ channel induced by sustained membrane depolarization. In cell-attached patch clamp recordings of rNav1.2 channels expressed in CHO cells, we found complex non-linear changes in the molecular kinetic properties, including channel dwell times and unitary conductance of single Na+ channels that were dependent on the extent of conditioning membrane depolarization. A “molecular memory” phenomenon arises at longer depolarization characterized by clusters of dwell time events and strong autocorrelation in dwell times. Hidden Markov Modeling (HMM) ... suggested a possible explanation to the memory phenomenon. See paper for more and details.

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