||" ... Computer simulations confirmed that pharmacological enhancement
of KCNQ/Kv7 channel (M current) activity decreases excitability and
also suggested that the effects of inhibition of KCNQ/Kv7 channels on
the excitability of spinal MNs do not depend on a direct effect in
these neurons but likely on spinal cord synaptic partners. These
results indicate that KCNQ/Kv7 channels have a fundamental role in the
modulation of the excitability of spinal MNs acting both in these
neurons and in their local presynaptic partners. ..."