Models that contain the Implementer : Zang, Yunliang

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    Models   Description
1.  Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
"Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. ... The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals."

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