Models that contain the Modeling Application : MCell (Home Page)

(MCell, makes it possible to incorporate high resolution ultrastructure into models of ligand diffusion and signaling, and has evolved from experimental and theoretical work of the MCell gang: Joel Stiles (Biomedical Applications, Pittsburgh Supercomputing Center), Miriam Salpeter (Neurobiology & Behavior, Cornell University), Edwin Salpeter (Department of Physics and Astronomy, Cornell University), and Thomas Bartol and Terrence Sejnowski (Computational Neurobiology Laboratory, Salk Institute).)
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    Models   Description
1.  Active zone model of Ca2+ secretion coupling (Keller et al. 2015)
"... At a large model synapse, the calyx of Held, transmitter release is controlled by several Ca2+ channels in a "domain overlap" mode, at least in young animals. To study the geometrical constraints of Ca2+ channel placement in domain overlap control of release, we used stochastic MCell modelling, at active zones for which the position of docked vesicles was derived from electron microscopy (EM). ..."
2.  Analytical modelling of temperature effects on an AMPA-type synapse (Kufel & Wojcik 2018)
This code was used in the construction of the model developed in the paper. It is a modified version of the simulation developed by Postlethwaite et al. 2007 - for details of modifications refer to the main body of Kufel & Wojcik (2018).
3.  Modeling temperature changes in AMPAR kinetics (Postlethwaite et al 2007)
This model was used to simulate glutamatergic, AMPA receptor mediated mEPSCs (miniature EPSCs, resulting from spontaneous vesicular transmitter release) at the calyx of Held synapse. It was used to assess the influence of temperature (physiological vs. subphysiological) on the amplitude and time course of mEPSCs. In the related paper, simulation results were directly compared to the experimental data, and it was concluded that an increase of temperature accelerates AMPA receptor kinetics.

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