||These mod files supplied by Dr Raman are for the below two references. ... we modeled action potential firing by simulating eight currents directly recorded from Purkinje cells in both wild-type and (mutant) med mice.
Regular, high-frequency firing was slowed in med Purkinje neurons. In addition to disrupted sodium currents, med neurons had small
but significant changes in potassium and leak currents. Simulations indicated that these modified non-sodium currents could not
account for the reduced excitability of med cells but instead slightly facilitated spiking. The loss of NaV1.6-specific kinetics, however,
slowed simulated spontaneous activity. Together, the data suggest that across a range of conditions, sodium currents with a resurgent
component promote and accelerate firing. See papers for more and details.