| || Models ||Description|
Kinetics of the P2X7 receptor as expressed in Xenopus oocytes (Riedel et al. 2007a,b)
||"Human P2X7 receptors were expressed in Xenopus laevis oocytes and
single channels were recorded using the patch-clamp technique in the
outside-out configuration. ATP4- evoked two types of P2X7
receptor-mediated single channel currents characterized by short-lived
and long-lived openings. ... The kinetics of the short channel
openings at negative membrane potentials fitted well to a linear
C-C-C-O model with two ATP4- binding steps at equal binding sites
...." and "Using the patch-clamp method, we studied the influence of
external alkali and organic monovalent cations on the single-channel
properties of the adenosine triphosphate (ATP)-activated recombinant
human P2X(7) receptor." See the references for more.
Microglial cytokine network (Anderson et al., 2015)
||This is an ODE model of autocrine/paracrine microglial cytokine interactions. Simulations include analyses of neuroinflammation mechanisms in the context of adaptation and tolerance to LPS.