| | Models | Description |
| 1. |
A detailed Purkinje cell model (Masoli et al 2015)
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The Purkinje cell is one of the most complex type of neuron in the central nervous system and is well known for its massive dendritic tree. The initiation of the action potential was theorized to be due to the high calcium channels presence in the dendritic tree but, in the last years, this idea was revised. In fact, the Axon Initial Segment, the first section of the axon was seen to be critical for the spontaneous generation of action potentials. The model reproduces the behaviours linked to the presence of this fundamental sections and the interplay with the other parts of the neuron. |
| 2. |
Ionic mechanisms of bursting in CA3 pyramidal neurons (Xu and Clancy 2008)
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"... We present a single-compartment model of a CA3 hippocampal pyramidal neuron based on recent experimental data. We then use the model to determine the roles of primary depolarizing currents in burst generation.
The single compartment
model incorporates accurate representations of sodium (Na+) channels (NaV1.1) and T-type calcium (Ca2+) channel subtypes
(CaV3.1, CaV3.2, and CaV3.3).
Our simulations predict the importance of Na+ and T-type Ca2+ channels in hippocampal
pyramidal cell bursting and reveal the distinct contribution of each subtype to burst morphology.
We also performed fastslow
analysis in a reduced comparable model, which shows that our model burst is generated as a result of the interaction
of two slow variables, the T-type Ca2+ channel activation gate and the Ca2+-dependent potassium (K+) channel activation
gate.
The model reproduces a range of experimentally observed phenomena including afterdepolarizing potentials, spike widening at the end of the burst, and rebound.
Finally, we use the model to simulate the effects of two epilepsy-linked
mutations: R1648H in NaV1.1 and C456S in CaV3.2, both of which result in increased cellular excitability."
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| 3. |
Learning intrinsic excitability in Medium Spiny Neurons (Scheler 2014)
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"We present an unsupervised, local activation-dependent learning rule for intrinsic plasticity (IP) which affects the composition of ion channel conductances for single neurons in a use-dependent way.
We use a single-compartment conductance-based model for medium spiny striatal neurons in order to show the effects of parameterization of individual ion channels on the neuronal membrane potential-curent relationship (activation function).
We show that parameter changes within the physiological ranges are sufficient to create an ensemble of neurons with significantly different activation functions.
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| 4. |
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
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Python and MATLAB scripts for studying the dual effects of SCZ-related genes on layer 5 pyramidal cell firing and sinoatrial node cell pacemaking properties. The study is based on two L5PC models (Hay et al. 2011, Almog & Korngreen 2014) and SANC models (Kharche et al. 2011, Severi et al. 2012). |
| 5. |
Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
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Python scripts for running NEURON simulations that model a layer V pyramidal cell with certain genetic variants implemented. The genes included are obtained from genome-wide association studies of schizophrenia. |
| 6. |
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
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" … Here, using computational modeling,
we show that a common biomarker of schizophrenia, namely, an increase in delta-oscillation power, may be a direct
consequence of altered expression or kinetics of voltage-gated ion channels or calcium transporters. Our model of a circuit
of layer V pyramidal cells highlights multiple types of schizophrenia-related variants that contribute to altered dynamics in
the delta frequency band. Moreover, our model predicts that the same membrane mechanisms that increase the layer V
pyramidal cell network gain and response to delta-frequency oscillations may also cause a decit in a single-cell correlate of
the prepulse inhibition, which is a behavioral biomarker highly associated with schizophrenia." |
| 7. |
Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)
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We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity. |
| 8. |
T-type Calcium currents (McRory et al 2001)
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NEURON mod files for CaT currents from the paper
McRory et al., J.Biol.Chem. 276:3999 (2001).
In this paper, three members (alpha-1G, -1H, and -1I) of the LVA calcium channels family were studied. Kinetic parameters were derived from functional expression in transfected cells. |
