||" ... We evaluated the impact of molecular variability in the expression of cell signaling components and ion channels
on electrophysiological excitability and neuromodulation. We employed a computational approach that integrated neuropeptide receptor-mediated signaling with electrophysiology. We simulated a population of neurons in which expression levels of a neuropeptide receptor and multiple ion channels were simultaneously
varied within a physiological range. We analyzed the effects of variation on the electrophysiological response to a neuropeptide stimulus. ..."