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In our experimental study, we combined
paired patch-clamp recordings and two-photon
Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with
detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al.,
2003, modelDB accession # 20212. |
