Models that contain the Implementer : David, Tim

Re-display model names without descriptions
    Models   Description
1.  A mathematical model of a neurovascular unit (Dormanns et al 2015, 2016) (Farrs & David 2011)
Here a lumped parameter numerical model of a neurovascular unit is presented, representing an intercellular communication system based on ion exchange through pumps and channels between neurons, astrocytes, smooth muscle cells, endothelial cells, and the spaces between these cells: the synaptic cleft between the neuron and astrocyte, the perivascular space between the astrocyte and SMC, and the extracellular space surrounding the cells. The model contains various cellular and chemical pathways such as potassium, astrocytic calcium, and nitric oxide. The model is able to simulate neurovascular coupling, the process characterised by an increase in neuronal activity followed by a rapid dilation of local blood vessels and hence increased blood supply providing oxygen and glucose to cells in need.
2.  A model of neurovascular coupling and the BOLD response (Mathias et al 2017, Kenny et al 2018)
Here a lumped parameter numerical model of a neurovascular unit is presented, representing an intercellular communication system based on ion exchange through pumps and channels between neurons, astrocytes, smooth muscle cells, endothelial cells, and the spaces between these cells: the synaptic cleft between the neuron and astrocyte, the perivascular space between the astrocyte and SMC, and the extracellular space surrounding the cells. The model contains various cellular and chemical pathways such as potassium, astrocytic calcium, and nitric oxide. The model is able to simulate neurovascular coupling, the process characterised by an increase in neuronal activity followed by a rapid dilation of local blood vessels and hence increased blood supply providing oxygen and glucose to cells in need. The model also incorporates the BOLD response.

Re-display model names without descriptions