||" … Here, using computational modeling,
we show that a common biomarker of schizophrenia, namely, an increase in delta-oscillation power, may be a direct
consequence of altered expression or kinetics of voltage-gated ion channels or calcium transporters. Our model of a circuit
of layer V pyramidal cells highlights multiple types of schizophrenia-related variants that contribute to altered dynamics in
the delta frequency band. Moreover, our model predicts that the same membrane mechanisms that increase the layer V
pyramidal cell network gain and response to delta-frequency oscillations may also cause a decit in a single-cell correlate of
the prepulse inhibition, which is a behavioral biomarker highly associated with schizophrenia."