Models that contain the Current : I_KHT

Re-display model names without descriptions
    Models   Description
1.  Active dendritic action potential propagation (Casale & McCormick 2011)
This model explores the dendritic sodium and potassium conductances needed to recapitulate voltage-sensitive dye optical recordings of thalamic interneuron dendrites in the dorsal lateral geniculate nucleus. Model ion channels were selected based on pharmacological data.
2.  Calcium and potassium currents of olfactory bulb juxtaglomerular cells (Masurkar and Chen 2011)
Inward and outward currents of the olfactory bulb juxtaglomerular cells are characterized in the experiments and modeling in these two Masurkar and Chen 2011 papers.
3.  Modelling platform of the cochlear nucleus and other auditory circuits (Manis & Compagnola 2018)
"Models of the auditory brainstem have been an invaluable tool for testing hypotheses about auditory information processing and for highlighting the most important gaps in the experimental literature. Due to the complexity of the auditory brainstem, and indeed most brain circuits, the dynamic behavior of the system may be difficult to predict without a detailed, biologically realistic computational model. Despite the sensitivity of models to their exact construction and parameters, most prior models of the cochlear nucleus have incorporated only a small subset of the known biological properties. This confounds the interpretation of modelling results and also limits the potential future uses of these models, which require a large effort to develop. To address these issues, we have developed a general purpose, bio-physically detailed model of the cochlear nucleus for use both in testing hypotheses about cochlear nucleus function and also as an input to models of downstream auditory nuclei. The model implements conductance-based Hodgkin-Huxley representations of cells using a Python-based interface to the NEURON simulator. ..."
4.  Properties of aconitine-induced block of KDR current in NG108-15 neurons (Lin et al. 2008)
"The effects of aconitine (ACO), a highly toxic alkaloid, on ion currents in differentiated NG108-15 neuronal cells were investigated in this study. ACO (0.3-30 microM) suppressed the amplitude of delayed rectifier K+ current (IK(DR)) in a concentration-dependent manner with an IC50 value of 3.1 microM. The presence of ACO enhanced the rate and extent of IK(DR) inactivation, although it had no effect on the initial activation phase of IK(DR). ... A modeled cell was designed to duplicate its inhibitory effect on spontaneous pacemaking. ... Taken together, the experimental data and simulations show that ACO can block delayed rectifier K+ channels of neurons in a concentration- and state-dependent manner. Changes in action potentials induced by ACO in neurons in vivo can be explained mainly by its blocking actions on IK(DR) and INa."
5.  Pyramidal neurons: IKHT offsets activation of IKLT to increase gain (Fernandez et al 2005)
This matlab model was supplied by Dr Fernandez. It provides the model specification for the below paper. The influence of a high threshold K current on low threshold K and Na currents (especially frequency-current relationships) are studied in the paper with both experiments and modeling. Please see the reference for more and details.
6.  Simulation studies on mechanisms of levetiracetam-mediated inhibition of IK(DR) (Huang et al. 2009)
Levetiracetam (LEV) is an S-enantiomer pyrrolidone derivative with established antiepileptic efficacy in generalized epilepsy and partial epilepsy. However, its effects on ion currents and membrane potential remain largely unclear. In this study, we investigated the effect of LEV on differentiated NG108-15 neurons. ... Simulation studies in a modified Hodgkin-Huxley neuron and network unraveled that the reduction of slowly inactivating IK(DR) resulted in membrane depolarization accompanied by termination of the firing of action potentials in a stochastic manner. Therefore, the inhibitory effects on slowly inactivating IK(DR) (Kv3.1-encoded current) may constitute one of the underlying mechanisms through which LEV affects neuronal activity in vivo.
7.  Zebrafish Mauthner-cell model (Watanabe et al 2017)
The NEURON model files encode the channel generator and firing simulator for simulating development and differentiation of the Mauthner cell (M-cell) excitability in zebrafish. The channel generator enables us to generate arbitrary Na+ and K+ channels by changing parameters of a Hodgkin-Huxley model under emulation of two-electrode voltage-clamp recordings in Xenopus oocyte system. The firing simulator simulates current-clamp recordings to generate firing patterns of the model M-cell, which are implemented with arbitrary-generated basic Na+ and K+ conductances and low-threshold K+ channels Kv7.4/KCNQ4 and sole Kv1.1 or Kv1.1 coexpressed with Kvbeta2.

Re-display model names without descriptions