| | Models | Description |
| 1. |
A single kinetic model for all human voltage-gated sodium channels (Balbi et al, 2017)
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Code for simulating macroscopic currents of sodium channels (Nav1.1. to Nav1.9), by means of a single kinetic model. Intensity-voltage curves, normalized conductance-voltage relationship, steady-state availability and recovery from inactivation are simulated. |
| 2. |
Intrinsic sensory neurons of the gut (Chambers et al. 2014)
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A conductance base model of intrinsic neurons neurons in the gastrointestinal tract. The model contains all the major voltage-gated and calcium-gated currents observed in these neurons. This model can reproduce physiological observations such as the response to multiple brief depolarizing currents, prolonged depolarizing currents and hyperpolarizing currents. This model can be used to predict how different currents influence the excitability of intrinsic sensory neurons in the gut. |
| 3. |
Models of Na channels from a paper on the PKC control of I Na,P (Baker 2005)
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"The tetrodotoxin-resistant (TTX-r) persistent Na(+) current, attributed to Na(V)1.9, was recorded in small (< 25 mum apparent diameter) dorsal root ganglion (DRG) neurones cultured from P21 rats and from adult wild-type and Na(V)1.8 null mice. ... Numerical simulation of the up-regulation qualitatively reproduced changes in sensory neurone firing properties. ..." Note: models of NaV1.8 and NaV1.9 and also persistent and transient Na channels that collectively model Nav 1.1, 1.6, and 1.7 are present in this model. |
| 4. |
TTX-R Na+ current effect on cell response (Herzog et al 2001)
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"Small dorsal root ganglion (DRG) neurons, which include nociceptors,
express multiple voltage-gated sodium currents. In addition to a
classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium
current, many of these cells express a TTX-resistant (TTX-R) sodium
current that activates near -70 mV and is persistent at negative
potentials. To investigate the possible contributions of this TTX-R
persistent (TTX-RP) current to neuronal excitability, we carried out
computer simulations using the Neuron program with TTX-S and -RP
currents, fit by the Hodgkin-Huxley model, that closely matched the
currents recorded from small DRG neurons. ..." See paper for more and details. |
