ModelDB: Thalamic interneuron multicompartment model (Zhu et al. 1999)

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Thalamic interneuron multicompartment model (Zhu et al. 1999)
Accession: 116862
this is an attempt to recreate a set of simulations originally performed in 1994 under NEURON version 3 and last tested in 1999. When I ran it now it did not behave exactly the same as previously which I suspect is due to some minor mod file changes on my side rather than due to any differences among versions. After playing around with the parameters a little bit I was able to get something that looks generally like a physiological trace in J Neurophysiol, 81:702--711, 1999, fig. 8b top trace. This sad preface is simply offered in order to encourage anyone who is interested in this model to make and post fixes. I'm happy to help out. Simulation by JJ Zhu To run nrnivmodl nrngui.hoc
References:
1. Zhu JJ, Uhlrich DJ, Lytton WW (1999) Burst firing in identified rat geniculate interneurons. Neuroscience 91:1445-60 [PubMed]
2. Zhu JJ, Lytton WW, Xue JT, Uhlrich DJ (1999) An intrinsic oscillation in interneurons of the rat lateral geniculate nucleus. J Neurophysiol 81:702-11 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  Thalamus;
Cell Type(s):   
Channel(s):  I Na,t; I L high threshold; I T low threshold; I K,leak; I h; I K,Ca; I CAN;  
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  
Simulation Environment:  NEURON;
Model Concept(s):  Bursting; Oscillations;
Implementer(s):  Zhu, J. Julius [jjzhu at virginia.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I T low threshold; I K,leak; I h; I K,Ca; I CAN;
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b09jan13
readme.html
screenshot.jpg
cadecay.mod
clampex.mod *
cp.mod *
cp2.mod *
GABAA.mod
GABAB.mod
HH2.mod *
Iahp.mod *
Ican.mod *
Ih.mod *
IL.mod
IL3.mod *
IT.mod *
IT2.mod *
kdr2.mod *
kleak.mod *
kmbg.mod
naf2.mod *
nap.mod *
NMDA.mod
nthh.mod *
ntIh.mod *
ntleak.mod
ntt.mod *
pregencv.mod
AMPA.mod
vecst.mod
mosinit.hoc *
batch_.hoc
misc.h
bg_cvode.inc
netcon.inc
                            
This is the readme for the model associated with the papers:

1. Zhu JJ, Uhlrich DJ, Lytton WW (1999) Burst firing in identified rat
geniculate interneurons. Neuroscience 91:1445-60

2. Zhu JJ, Lytton WW, Xue JT, Uhlrich DJ (1999) An intrinsic
oscillation in interneurons of the rat lateral geniculate nucleus. J
Neurophysiol 81:702-11

These model files were supplied by Bill Lytton with the following
disclaimer:

This is an attempt to recreate a set of simulations originally
performed in 1994 under NEURON version 3 and last tested in 1999. When
I ran it now it did not behave exactly the same as previously which I
suspect is due to some minor mod file changes on my side rather than
due to any differences among versions. After playing around with the
parameters a little bit I was able to get something that looks
generally like a physiological trace in J Neurophysiol, 81:702--711,
1999, fig. 8b top trace:

screenshot

This sad preface is simply offered in order to encourage anyone who is
interested in this model to make and post fixes. I'm happy to help
out. Simulation by JJ Zhu

To run 

nrnivmodl
nrngui mosinit.hoc
 
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