CA3 pyramidal neuron: firing properties (Hemond et al. 2008)

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Accession:101629
In the paper, this model was used to identify how relative differences in K+ conductances, specifically KC, KM, & KD, between cells contribute to the different characteristics of the three types of firing patterns observed experimentally.
Reference:
1 . Hemond P, Epstein D, Boley A, Migliore M, Ascoli GA, Jaffe DB (2008) Distinct classes of pyramidal cells exhibit mutually exclusive firing patterns in hippocampal area CA3b Hippocampus 18(4):411-24 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I CAN; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Active Dendrites; Detailed Neuronal Models; Action Potentials;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I CAN; I Calcium; I Potassium;
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ca3b
readme.html *
cacumm.mod *
cagk.mod *
cal2.mod *
can2.mod *
cat.mod *
distr.mod *
h.mod *
KahpM95.mod *
kaprox.mod *
kd.mod *
kdrca1.mod *
km.mod *
na3n.mod *
naxn.mod *
ca3b-cell1zr.hoc *
ca3b-cell1zr.ses *
fixnseg.hoc *
geo-cell1zr.hoc *
mosinit.hoc *
screenshot.jpg *
                            
TITLE CA1 KM channel from Mala Shah
: M. Migliore June 2006

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v 		(mV)
	ek
	celsius 	(degC)
	gbar=.0001 	(mho/cm2)
        vhalfl=-40   	(mV)
	kl=-10
        vhalft=-42   	(mV)
        a0t=0.003      	(/ms)
        zetat=7    	(1)
        gmt=.4   	(1)
	q10=5
	b0=60
	st=1
	sh =24
}


NEURON {
	SUFFIX km
	USEION k READ ek WRITE ik
        RANGE  gbar,ik, sh
      GLOBAL inf, tau
}

STATE {
        m
}

ASSIGNED {
	ik (mA/cm2)
        inf
	tau
        taua
	taub
}

INITIAL {
	rate(v)
	m=inf
}


BREAKPOINT {
	SOLVE state METHOD cnexp
	ik = gbar*m^st*(v-ek)
}


FUNCTION alpt(v(mV)) {
  alpt = exp(0.0378*zetat*(v-vhalft-sh)) 
}

FUNCTION bett(v(mV)) {
  bett = exp(0.0378*zetat*gmt*(v-vhalft-sh)) 
}

DERIVATIVE state {
        rate(v)
	m' = (inf - m)/tau
}

PROCEDURE rate(v (mV)) { :callable from hoc
        LOCAL a,qt
        qt=q10^((celsius-35)/10)
        inf = (1/(1 + exp((v-vhalfl-sh)/kl)))
        a = alpt(v)
        tau = b0 + bett(v)/(a0t*(1+a))
}















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